Cyclooxygenase-2 protein and prostaglandin E(2) production are up-regulated in a rat bladder inflammation model

European Journal of Pharmacology
M A WheelerR M Weiss

Abstract

Cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins and prostaglandin E(2) production are evaluated in a rat model of inflammation in which Escherichia coli lipopolysaccharide is intraperitoneally injected or intravesically instilled into the bladder. While cyclooxygenase-1 mRNA and protein and cyclooxygenase-2 mRNA do not change in bladders treated with lipopolysaccharide, cyclooxygenase-2 protein is elevated in bladders from rats intravesically instilled with lipopolysaccharide or phosphate buffered saline (PBS) or intraperitoneally injected with lipopolysaccharide. Urinary prostaglandin E(2) levels and prostaglandin E(2) synthesis in bladder particulates are elevated by intravesical instillation and intraperitoneal injection of lipopolysaccharide. The nitric oxide donor, S-nitroso-N-acetyl-D,L-penicillamine, increases prostaglandin E(2) synthesis in bladders from lipopolysaccharide intravesically instilled and intraperitoneally injected rats. Lipopolysaccharide increases prostaglandin E(2) synthesis by increasing cyclooxygenase-2 protein levels in rat bladder and prostaglandin E(2) synthesis may be further elevated by increases in nitric oxide caused by an up-regulation of inducible nitric oxide synthase (iNOS).

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Citations

Jul 13, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Frank J TamarkinRobert M Weiss
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katherine L Meyer-SieglerPedro L Vera
Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zun-Yi WangDale E Bjorling
Mar 7, 2008·American Journal of Physiology. Renal Physiology·Prerna RastogiJane McHowat
Apr 28, 2007·Urology·Omar NazifG F Gebhart
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Hala El-MesallamyNada Osama
Mar 27, 2007·The Journal of Urology·Beatriz E Linares-Fernández, Anna B Alfieri
Mar 22, 2003·Expert Review of Molecular Diagnostics·Marcia R SabanRicardo Saban
Apr 15, 2004·The Journal of Pharmacology and Experimental Therapeutics·Walter S KangRobert M Weiss
Apr 28, 2006·American Journal of Physiology. Renal Physiology·Li-Mei ChenKarl X Chai
Apr 29, 2015·British Journal of Pharmacology·Na N GuanLars E Gustafsson
Dec 17, 2005·Journal of Applied Physiology·V M DupouyH P Lefebvre
Feb 2, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Takashi KondoHiroto Miwa
Oct 22, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·V Y HuM A Vizzard
Jun 12, 2002·The American Journal of Pathology·Marcia R SabanRicardo Saban

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