Cyclooxygenase-catalyzed formation of 9-hydroxylinoleic acid by guinea pig alveolar macrophages under non-stimulated conditions

FEBS Letters
F EngelsF P Nijkamp


Data are presented on the formation of a linoleic acid oxygenation product under basal conditions by guinea pig alveolar macrophages (AM). Under non-stimulated conditions 20 X 10(6) AM released about 1 nmol 9-hydroxylinoleic acid (9-HODE) during a 15 min incubation. Furthermore, AM released more than 2 nmol 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), a byproduct of the formation of thromboxane A2. 9-HODE and HHT were the most prominent products formed under the incubation conditions used. These products were formed via a cyclooxygenase-catalyzed reaction, since their formation was inhibited by 1 microM indomethacin. Thus, under basal conditions AM possess substantial cyclooxygenase activity. The biological significance of 9-HODE and related substances is discussed.


Oct 23, 1985·Biochimica Et Biophysica Acta·M ClaeysD H Nugteren
May 29, 1986·Biochemical and Biophysical Research Communications·M HayakawaT Ozawa
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P S AisenG Weissmann
Feb 13, 1986·Biochemical and Biophysical Research Communications·T OzawaT Tomita
Sep 1, 1974·The Journal of Clinical Investigation·E GoldsteinD Warshauer
Feb 1, 1983·Biochemical Pharmacology·P BorgeatJ Maclouf
Jan 1, 1984·Prostaglandins, Leukotrienes, and Medicine·J VerhagenP L Bruynzeel

❮ Previous
Next ❯


Jan 1, 1993·Archives of Dermatological Research·B GrønK Kragballe
May 17, 1991·European Journal of Pharmacology·P A HenricksF P Nijkamp
Jan 1, 1987·International Journal of Immunopharmacology·P A HenricksF P Nijkamp
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·William L Smith, Inseok Song
Sep 11, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Christopher E RamsdenJ Douglas Mann
Sep 5, 2015·The Journal of Nutritional Biochemistry·Justine MarchixPhilippe Legrand
Apr 16, 2008·European Journal of Pharmacology·Alma J NautaFrank A Redegeld
Aug 1, 2013·Biochimie·Benjamin ChoquePhilippe Legrand
Dec 9, 2014·Biochimica Et Biophysica Acta·Giuseppe AstaritaAnna Nicolaou
Jun 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ameer Y TahaChristopher E Ramsden
Nov 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C LoesbergF P Nijkamp
Dec 6, 2017·PloS One·G Andres ContrerasLorraine M Sordillo
Nov 5, 2019·Frontiers in Pharmacology·Tabea Osthues, Marco Sisignano
Dec 20, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Zhichao ZhangAmeer Y Taha

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.