Cyclooxygenase-catalyzed formation of 9-hydroxylinoleic acid by guinea pig alveolar macrophages under non-stimulated conditions

FEBS Letters
F EngelsF P Nijkamp

Abstract

Data are presented on the formation of a linoleic acid oxygenation product under basal conditions by guinea pig alveolar macrophages (AM). Under non-stimulated conditions 20 X 10(6) AM released about 1 nmol 9-hydroxylinoleic acid (9-HODE) during a 15 min incubation. Furthermore, AM released more than 2 nmol 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT), a byproduct of the formation of thromboxane A2. 9-HODE and HHT were the most prominent products formed under the incubation conditions used. These products were formed via a cyclooxygenase-catalyzed reaction, since their formation was inhibited by 1 microM indomethacin. Thus, under basal conditions AM possess substantial cyclooxygenase activity. The biological significance of 9-HODE and related substances is discussed.

References

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Citations

Jan 1, 1993·Archives of Dermatological Research·B GrønK Kragballe
May 17, 1991·European Journal of Pharmacology·P A HenricksF P Nijkamp
Jan 1, 1987·International Journal of Immunopharmacology·P A HenricksF P Nijkamp
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·William L Smith, Inseok Song
Sep 11, 2012·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Christopher E RamsdenJ Douglas Mann
Sep 5, 2015·The Journal of Nutritional Biochemistry·Justine MarchixPhilippe Legrand
Apr 16, 2008·European Journal of Pharmacology·Alma J NautaFrank A Redegeld
Aug 1, 2013·Biochimie·Benjamin ChoquePhilippe Legrand
Dec 9, 2014·Biochimica Et Biophysica Acta·Giuseppe AstaritaAnna Nicolaou
Jun 11, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Ameer Y TahaChristopher E Ramsden
Nov 1, 1988·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C LoesbergF P Nijkamp
Dec 6, 2017·PloS One·G Andres ContrerasLorraine M Sordillo
Nov 5, 2019·Frontiers in Pharmacology·Tabea Osthues, Marco Sisignano
Dec 20, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Zhichao ZhangAmeer Y Taha

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