Cyclooxygenase inhibition attenuates cholecystokinin-induced gastroprotection

Digestive Diseases and Sciences
D W MercerT A Miller

Abstract

Cholecystokinin prevents gastric injury by an unknown mechanism. This study was conducted in conscious, fasted female rats in order to assess the role of endogenous prostaglandins as a potential protective mechanism for cholecystokinin-induced gastroprotection. Intravenous administration of cholecystokinin (0.05-5 nmol/kg) dose-dependently reduced macroscopic injury to the glandular portion of the stomach caused by 1 ml of orally administered acidified ethanol (150 mM hydrochloric acid-50% ethanol), an effect corroborated by histologic analysis. In time course studies, this protective action occurred as early as 10 min following cholecystokinin injection (5 nmol/kg intravenously), but was absent at 1 hr. Cyclooxygenase inhibition with either indomethacin (5 mg/kg intraperitoneally) or aspirin (100 mg/kg intraperitoneally) resulted in a partial reversal in cholecystokinin-induced gastroprotection, effects that were similar in magnitude. However, while indomethacin reduced gastric mucosal prostaglandin synthesis (enzyme-linked immunoassay) by 60%, aspirin almost totally abolished prostaglandin synthesis (95% reduction). Cholecystokinin (5 nmol/kg intravenously) did not significantly enhance gastric mucosal prostaglandin synthesis...Continue Reading

Citations

Apr 15, 2006·Digestive Diseases and Sciences·Sonlee D WestDavid W Mercer
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masato KomoriMasatsugu Hori
Apr 15, 2006·Digestive Diseases and Sciences·Emily K RobinsonDavid W Mercer
Nov 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sonlee D WestDavid W Mercer
Jun 12, 2003·World Journal of Gastroenterology : WJG·Bin CongHong-Yu You

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