Cyclooxygenase Inhibitors, Aspirin and Ibuprofen, Inhibit MHC-restricted Antigen Presentation in Dendritic Cells.

Immune Network
Hyun-Jin KimChong-Kil Lee

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain, reduce fever and inhibit inflammation. NSAIDs function mainly through inhibition of cyclooxygenase (COX). Growing evidence suggests that NSAIDs also have immunomodulatory effects on T and B cells. Here we examined the effects of NSAIDs on the antigen presenting function of dendritic cells (DCs). DCs were cultured in the presence of aspirin or ibuprofen, and then allowed to phagocytose biodegradable microspheres containing ovalbumin (OVA). After washing and fixing, the efficacy of OVA peptide presentation by DCs was evaluated using OVA-specific CD8 and CD4 T cells. Aspirin and ibuprofen at high concentrations inhibited both MHC class I and class II-restricted presentation of OVA in DCs. In addition, the DCs generated in the presence of low concentrations of the drugs exhibit a profoundly suppressed capability to present MHC-restricted antigens. Aspirin and ibuprofen did not inhibit the phagocytic activity of DCs, the expression level of total MHC molecules and co-stimulatory molecules on DCs. Ibuprofen rather increased the expression level of total MHC molecules and co-stimulatory molecules on DCs. These results demonstrate that aspirin and ibuprofen ...Continue Reading

References

Jul 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J KarttunenN Shastri
Aug 12, 1994·Science·E Kopp, S Ghosh
Jan 1, 1996·Advances in Immunology·W L Smith, D L Dewitt
Jun 3, 2000·Annual Review of Immunology·J BanchereauK Palucka
Aug 31, 2000·Annual Review of Biochemistry·W L SmithR M Garavito
Mar 13, 2001·Annual Review of Immunology·W R Heath, F R Carbone
Nov 9, 2001·The Journal of Biological Chemistry·Silvia Rossi PaccaniCosima T Baldari
Mar 5, 2002·British Journal of Clinical Pharmacology·Hubert BlainJean-Yves Jouzeau
Oct 3, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gillian M BorthwickHelen M Arthur
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young-Hee LeeChong-Kil Lee

❮ Previous
Next ❯

Citations

Oct 2, 2012·Annual Review of Medicine·Dingzhi Wang, Raymond N DuBois
Mar 15, 2011·Journal of Dietary Supplements·Andrea K MillerDavid M Shepherd
Feb 24, 2016·Phytochemistry·N Bhagya, K R Chandrashekar
Dec 17, 2011·International Immunopharmacology·Muzammal HussainMuti Ur Rehman
Mar 1, 2011·International Immunopharmacology·Young-Hee LeeChong-Kil Lee
Aug 27, 2014·Journal of Medical Virology·Jen-Yin ChenMiao-Lin Hu
Nov 2, 2014·International Journal of Epidemiology·Jen-Yin ChenMiao-Lin Hu
Oct 7, 2011·Mediators of Inflammation·Emily A Van VréHidde Bult
Jun 2, 2016·Human Vaccines & Immunotherapeutics·Ezzeldin SalehEmmanuel B Walter
May 20, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rose H ManjiliMasoud H Manjili
Jun 15, 2011·Current Opinion in Organ Transplantation·Alison J LeishmanPaul J Fairchild
Oct 24, 2020·Scientifica·Murad N AbualhasanNael S Abu-Hasan
Feb 12, 2020·International Immunopharmacology·Urban Švajger, Primož J Rožman
Jun 4, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hsin-Fu Yeh
Aug 5, 2021·Lab on a Chip·Matthew R CarstensBenjamin G Keselowsky

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
ELISA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.