PMID: 6798171Oct 1, 1981Paper

Cyclooxygenase products of arachidonic acid metabolism in cat cerebral cortex after experimental concussive brain injury

Journal of Neurochemistry
E F EllisH A Kontos

Abstract

Previous studies have suggested that following experimental fluid percussion brain injury, increased prostaglandin (PG) synthesis, with its concomitant production of oxygen free radicals, causes functional and morphological abnormalities of the cerebral arterioles. The purpose of this study was to chemically determine if PGs are altered following this injury. To facilitate interpretation of neurochemical measurements the cats were ventilated, blood pressure was measured, and a cranial window, for microscopic observation of pial arteriolar diameter was inserted. PG levels were determined in quick-frozen cortical tissue removed from control and 3 groups of injured cats at 1.5, 8,0, and 60 min after injury. Analysis of PGE2, PGF2 alpha, and 6-keto-PGF1 alpha was performed by HPLC and GC/MS. The control levels of PGE2, PGF2 alpha, and 6-keto-PGF1 alpha were 216 +/- 44, 210 +/- 48, and 48 +/- 12 ng/g wet weight, respectively. Following injury, produced by a 22 ms increase in intracranial pressure, the pial arterioles dilated irreversibly and a transient hypertensive response occurred, thereby producing hyperemia. During the maximum hyperemic response, the total PGs were 75% of control. At 8 min after injury, when blood pressure retu...Continue Reading

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Citations

Aug 1, 1987·Neurochemical Pathology·R Saunders, L A Horrocks
Dec 1, 1987·Brain Research·H P Hartung, K V Toyka
Jun 27, 1996·European Journal of Pharmacology·M A PettyJ Wagner
Jul 1, 1986·Journal of the Neurological Sciences·C Y HsuR D Cox
Jan 1, 1988·Journal of the Neurological Sciences·C Y HsuH F Martin
Jan 1, 1988·Free Radical Biology & Medicine·G M Rubanyi
Jun 1, 1997·Surgical Neurology·D AwasthiW A Pryor
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P DemediukL A Horrocks
Jan 10, 2002·Journal of Neurotrauma·B M BellanderM Svensson
Dec 20, 2002·Journal of Neurotrauma·Dimitry Baranov, William M Armstead
Feb 21, 2002·Journal of Neurotrauma·Sean D HurleyM Kerry O'Banion
Oct 28, 2003·Journal of Neurotrauma·Douglas S DeWitt, Donald S Prough
Mar 6, 2004·Journal of Neurotrauma·Jonathan Ford, William M Armstead
Jan 1, 1988·Journal of Neurotrauma·X Q YuanD S Dewitt
Jan 1, 1990·Journal of Neurotrauma·Y ShapiraE Shohami
Jan 1, 1992·Journal of Neurotrauma·M R PrasadT K McIntosh
Jan 1, 1993·Journal of Neurotrauma·D L HiltonJ T Robertson
Dec 1, 1995·Journal of Neurotrauma·H S DhillonM Renuka Prasad
Apr 1, 1995·Journal of Neurotrauma·J K MuirE F Ellis
Sep 30, 1998·Journal of Neurotrauma·W M Armstead
Jun 16, 1999·Journal of Neurotrauma·W M Armstead

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