Cyclophilin A: A Predictive Biomarker of Carotid Stenosis in Cerebral Ischemic Stroke

Current Neurovascular Research
Chen-Shu ChangChin-San Liu

Abstract

Cyclophilin A plays a pathogenic role in the development and progression of atherosclerosis, which can be assessed by measuring carotid intima-media thickness. The primary aim of this study was to examine the interaction between plasma Cyclophilin A level and carotid intima-media thickness in patients with acute ischemic stroke. Plasma concentration of Cyclophilin A was measured on admission in 66 consecutive patients who had been hospitalized for acute cerebral stroke and in 52 case-control subjects without a history of acute stroke. Subjects in both groups also underwent ultrasound B-mode imaging to measure the mean and maximum intima-media thickness of the carotid artery. Inflammatory biomarkers including high-sensitivity C-reactive protein and fibrinogen were also assessed. We found that the plasma concentration of Cyclophilin A was significantly higher in patients with acute ischemic stroke (p = 0.042). Increased Cyclophilin A was also correlated with carotid intima-media thickness in the patient group (p < 0.001). Among the risk factors for cerebral stroke examined in this study, only hypertension was significantly associated with plasma Cyclophilin A level. Increased plasma Cyclophilin A levels might be involved in the p...Continue Reading

Citations

Dec 24, 2019·Expert Opinion on Investigational Drugs·Daren R UreRobert T Foster
Nov 2, 2019·The Kaohsiung Journal of Medical Sciences·Chen-Shu ChangChin-San Liu
Oct 1, 2020·Clinical Linguistics & Phonetics·Veronika VinczeJános Kálmán
Apr 3, 2019·Journal of Medical Internet Research·Yonglai ZhangWenai Song

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