Cyclophosphamide impairs hippocampus-dependent learning and memory in adult mice: Possible involvement of hippocampal neurogenesis in chemotherapy-induced memory deficits

Neurobiology of Learning and Memory
Miyoung YangChangjong Moon

Abstract

Cyclophosphamide (CYP) is an anti-neoplastic agent as well as an immunosuppressive agent. In order to elucidate the alteration in adult hippocampal function following acute CYP treatment, hippocampus-related behavioral dysfunction and changes in adult hippocampal neurogenesis in CYP-treated (intraperitoneally, 40 mg/kg) mice (8-10-week-old ICR) were analyzed using hippocampus-dependent learning and memory tasks (passive avoidance and object recognition memory test) and immunohistochemical markers of neurogenesis (Ki-67 and doublecortin (DCX)). Compared to the vehicle-treated controls, mice trained at 12h after CYP injection showed significant memory deficits in passive avoidance and the object recognition memory test. The number of Ki-67- and DCX-positive cells began to decrease significantly at 12h post-injection, reaching the lowest level at 24h after CYP injection; however, this reverted gradually to the vehicle-treated control level between 2 and 10 days. We suggest that the administration of a chemotherapeutic agent in adult mice interrupts hippocampal functions, including learning and memory, possibly through the suppression of hippocampal neurogenesis.

References

Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·P E Mirkes
Mar 11, 1999·Current Opinion in Neurobiology·S Temple, A Alvarez-Buylla
Jul 17, 1999·Brain Research. Molecular Brain Research·W PeissnerF Gillardon
Jan 12, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tim A AhlesPeter M Silberfarb
Aug 28, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S B SchagenF S A M van Dam
Jun 26, 2004·Annual Review of Neuroscience·Larry R SquireRobert E Clark
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Helen G Mar FanIan F Tannock
Nov 5, 2005·Oncology Nursing Forum·Catherine JansenJoel Kramer
Jan 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Garrick D LeeDonald K Ingram
Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·André B ReirizGilberto Schwartsmann
Dec 7, 2006·Journal of the National Cancer Institute·Sanne B SchagenFrits S A M van Dam
Aug 7, 2007·Critical Reviews in Oncology/hematology·Janette Vardy, Ian Tannock
May 2, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ming ZhangHongbing Wang

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Citations

Aug 21, 2013·Brain Imaging and Behavior·R SeigersJ Dietrich
Feb 12, 2014·Brain, Behavior, and Immunity·Miyoung YangChangjong Moon
Apr 20, 2014·Cellular and Molecular Neurobiology·Ewa Rojczyk-GołębiewskaRyszard Wiaderkiewicz
Mar 22, 2012·Canadian Journal of Physiology and Pharmacology·Mohammad ShabaniNader Shahrokhi
Dec 8, 2014·Physiology & Behavior·Maryam RadahmadiNasrin Hosseini
Aug 2, 2011·Behavioural Brain Research·Woon Ryoung KimHongjun Song
Apr 5, 2011·Biochemical Pharmacology·Miyoung YangChangjong Moon
Nov 26, 2015·Behavioural Brain Research·R SeigersS B Schagen
Mar 10, 2016·Neurotoxicology·Dorothée C-M VercruysseFrederic Amant
Jun 19, 2015·Neuroscience·J DietrichJ Kaiser
Mar 15, 2011·The European Journal of Neuroscience·Muriel Koehl, Djoher N Abrous
Dec 23, 2015·Neural Regeneration Research·Miyoung Yang, Changjong Moon
Jun 24, 2015·Behavioural Brain Research·Kaliris Y Salas-RamirezKaren Hubbard
Dec 1, 2010·Toxicological Research·Miyoung YangChangjong Moon
Sep 18, 2015·Neural Plasticity·Suk-yu YauKwok-Fai So
Dec 23, 2014·Neuropharmacology·Katharina BöscheMartin Hadamitzky
Sep 28, 2010·Neuroscience and Biobehavioral Reviews·Riejanne Seigers, Joanna E Fardell
Oct 25, 2011·Pharmacology, Biochemistry, and Behavior·Thane FremouwYamil Burguete
Jan 18, 2015·Brain, Behavior, and Immunity·Yeonghoon SonChangjong Moon
Jun 4, 2013·Biochemical and Biophysical Research Communications·Jin-Gang HouChang-Keun Sung
Jun 5, 2014·Psychopharmacology·R SeigersS B Schagen
Aug 25, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Lauren E HimmelSamuel K Kulp
Dec 12, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy J FlaniganSherry A Ferguson
Nov 2, 2016·Food & Function·Jisun Oh, Jong-Sang Kim
Mar 23, 2012·Journal of Veterinary Science·Miyoung YangChangjong Moon

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