Cyclophosphamide in dermatology

The Australasian Journal of Dermatology
Janet Kim, Jonathan J Chan

Abstract

Cyclophosphamide is a chemotherapeutic agent which was first discovered in experimental tumours in rats, and it has since been widely used to treat malignancies and severe manifestations of various auto-immune diseases. High-dose chemotherapy and continuous daily oral regimens are associated with significant toxicity profiles, but i.v. pulsed regimens have lowered the rates of adverse effects in rheumatological studies. Cyclophosphamide has been shown to be useful in the treatment of severe autoimmune conditions due to its powerful immunosuppressive ability; however, it remains a relatively underused modality in dermatology. This article reviews the current literature on cyclophosphamide and its clinical applications in dermatology.

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Citations

May 27, 2020·Oxidative Medicine and Cellular Longevity·Muluken Altaye AyzaAbera Hadgu Berhe
Sep 19, 2020·Journal of Experimental Pharmacology·Muluken Altaye AyzaAbera Hadgu Berhe
Nov 30, 2018·Frontiers in Pharmacology·Luca FalzoneMassimo Libra
Nov 14, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven E JohnsonMing Zhao
Nov 14, 2020·Clinical Science·Alexa N CarreraBeshay N Zordoky
May 6, 2021·International Journal of Dermatology·Lauren J FriedMiriam K Pomeranz
Aug 20, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Wenjing ZhangKuan Lai

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