PMID: 15334202Aug 31, 2004Paper

Cyclophosphamide in the treatment of focal segmental glomerulosclerosis

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
R MartinelliH Rocha

Abstract

Prednisone is the initial treatment of primary focal segmental glomerulosclerosis. However, when immunosuppressive agents in combination with steroids are used in the treatment of prednisone-dependent and prednisone-resistant patients the remission rate is variable. We report a long-term trial using cyclophosphamide (2.0 to 3.0 mg/kg body weight for 12 weeks) in combination with prednisone (1.0 to 2.0 mg/kg body weight), as compared with prednisone alone for the treatment of prednisone-resistant and frequently relapsing nephrotic syndrome and focal segmental glomerulosclerosis. Fifty-four patients (34 males and 20 females) with a diagnosis of idiopathic nephrotic syndrome and focal segmental glomerulosclerosis, followed-up for an average of 86.1 +/- 82.4 months, were evaluated. Complete remission occurred in 20.4% and partial remission in 14.8% of the patients treated with steroids and in 26.7 and 20.0% of the patients treated with cyclophosphamide + prednisone, respectively. Of the 24 prednisone-resistant patients treated with steroids in combination with cyclophosphamide, 33.3% obtained a complete/partial response. At the time of final evaluation, 25% of the patients treated with prednisone and 10.0% of those treated with pre...Continue Reading

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Mar 28, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M Hodson, Jonathan C Craig
Oct 30, 2013·The Cochrane Database of Systematic Reviews·Nanthiya PravitsitthikulJonathan C Craig
Mar 19, 2015·The Cochrane Database of Systematic Reviews·Deirdre HahnJonathan C Craig
Apr 1, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jasjeet SandhuKarambir S Gill

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