Cyclophosphamide-induced suppressor cells in mice: suppression of the antibody response in vitro and characterization of the effector cells

Cellular Immunology
M SegreD Segre

Abstract

It was found earlier that nonspecific suppressor cells obtained from the spleen of mice injected with cyclophosphamide (Cy) at a dose of 200 mg/kg body wt are nonadherent, surface Ig negative, and Thy-1 negative. It is now reported that Cy-induced suppressor (Cy-S) cells suppress the in vitro primary and secondary humoral responses in a dose-dependent manner. Suppressor activity is a property of a low density cell that is found in the spleen from 5 to 11 days after Cy administration. Cy-S cells are negative for a number of T-cell markers and are nonadherent to plastic. They are not agglutinated by peanut agglutinin and do not acquire the Thy-1 antigen after treatment with thymosin, suggesting that they are not T-cell precursors. While NK activity was detected in the Cy-S cell preparations, this activity was removed by treatment with antibodies specific for the Qa-5 antigen and complement without affecting the suppressor activity. Cy-S cells are, therefore, distinct from B cells, T cells, NK cells, and macrophages.

References

Aug 1, 1982·Immunopharmacology·K R McIntoshD Segre
Aug 1, 1982·Immunopharmacology·E H GreeleyD Segre
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Related Concepts

Metazoa
Antibody Formation
Cell Adhesion
Cyclophosphamide, (S)-Isomer
H-2 Antigens
Mice, Inbred Strains
Spleen
Colony-forming Unit
T-Lymphocyte
Tr1 Cells

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