Cyclophosphamide-induced suppressor cells in mice: suppression of the antibody response in vitro and characterization of the effector cells

Cellular Immunology
M SegreD Segre


It was found earlier that nonspecific suppressor cells obtained from the spleen of mice injected with cyclophosphamide (Cy) at a dose of 200 mg/kg body wt are nonadherent, surface Ig negative, and Thy-1 negative. It is now reported that Cy-induced suppressor (Cy-S) cells suppress the in vitro primary and secondary humoral responses in a dose-dependent manner. Suppressor activity is a property of a low density cell that is found in the spleen from 5 to 11 days after Cy administration. Cy-S cells are negative for a number of T-cell markers and are nonadherent to plastic. They are not agglutinated by peanut agglutinin and do not acquire the Thy-1 antigen after treatment with thymosin, suggesting that they are not T-cell precursors. While NK activity was detected in the Cy-S cell preparations, this activity was removed by treatment with antibodies specific for the Qa-5 antigen and complement without affecting the suppressor activity. Cy-S cells are, therefore, distinct from B cells, T cells, NK cells, and macrophages.


Aug 1, 1982·Immunopharmacology·K R McIntoshD Segre
Aug 1, 1982·Immunopharmacology·E H GreeleyD Segre
Nov 11, 1983·Science·L V Abruzzo, D A Rowley


Jul 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·L N FontalinN V Mikheeva
Aug 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·T K Kondrat'evaL N Fontalin
Jun 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny·I Iu CherniakhovskaiaL N Fontalin
Jul 20, 2001·International Immunopharmacology·K InoJ E Talmadge
Oct 1, 1987·The Journal of Experimental Medicine·B Hertel-WulffS Strober
Feb 19, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·B Obmińska-DomoradzkaT Garbuliński
Jan 1, 1991·Annals of the New York Academy of Sciences·A V MitasovV V Kozlov
Jul 15, 2015·The Journal of Clinical Investigation·Douglas Marvel, Dmitry I Gabrilovich
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B PeláezJ L Subiza
Aug 15, 1989·International Journal of Cancer. Journal International Du Cancer·J L SubizaE G De La Concha

Related Concepts

Antibody Formation
Cell Adhesion
Cyclophosphamide, (S)-Isomer
H-2 Antigens
Mice, Inbred Strains
Colony-forming Unit
Tr1 Cells

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.