PMID: 11320665Apr 26, 2001Paper

Cyclophosphamide metabolism in children following a 1-h and a 24-h infusion

Cancer Chemotherapy and Pharmacology
S M YuleA V Boddy

Abstract

The pharmacokinetics and metabolism of cyclophosphamide (CPA) when given as a 1-h and a 24-h infusion to children were compared. Thirteen children with a variety of different malignancies received an identical dose of cyclophosphamide as a 1- and 24-h infusion. In each case the concentration of CPA and its principal metabolites were measured by a thin-layer-chromatography-photographic-densitometry technique. Cyclophosphamide clearance was greater during the 24-h infusion, following time-dependent increases in the metabolism of the drug (autoinduction) (median 5.1 vs 3.1 l/h/m2: P = 0.037). Autoinduction was seen in five children (38%), producing a median end of infusion concentration of 49% (range 28-89%) of the maximum and was not accompanied by an increase in the production of the principal inactive metabolites carboxyphosphamide and dechloroethylcyclophosphamide. These results suggest potential benefits of prolonging the infusion of CPA in clinical practice.

Citations

Oct 20, 2005·Clinical Pharmacokinetics·Milly E de JongeJos H Beijnen
Jan 6, 2006·Drug Metabolism Reviews·Jing ZhangYi-Zhun Zhu
Apr 26, 2016·Advances in Hematology·Sarita Rani Jaiswal, Suparno Chakrabarti
Jun 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jeannine S McCuneGeorge B McDonald
Sep 21, 2016·Cancer Chemotherapy and Pharmacology·Martina Ahlmann, Georg Hempel
Sep 13, 2005·Pediatric Blood & Cancer·Jeannine S McCuneClinton F Stewart
Apr 3, 2009·Developmental Neurorehabilitation·Mathilde P ChevignardAnne Laurent-Vannier

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