Cyclophosphamide mobilization does not improve outcome in patients receiving stem cell transplantation for multiple myeloma

Clinical Lymphoma & Myeloma
David DingliMorie A Gertz

Abstract

Patients with multiple myeloma who undergo autologous stem cell transplantation (ASCT) and exhibit a complete response (CR) have a superior overall survival and time to progression (TTP). High-dose cyclophosphamide is often used before ASCT for mobilization of hematopoietic stem cells. We hypothesized that cyclophosphamide might further improve CR rates in patients undergoing ASCT. We searched the Mayo Clinic myeloma transplantation database for patients who had stem cell mobilization with hematopoietic growth factor alone or cyclophosphamide and growth factor. The impact of cyclophosphamide on CR rates and TTP was evaluated. A cohort of 201 patients was identified: 127 mobilized with cyclophosphamide and growth factor and 74 with growth factor alone. There were no statistically significant differences between the 2 cohorts in regard to age, sex, b2-microglobulin level, plasma cell labeling index, cytogenetics, conditioning regimen, or disease status at time of transplantation. Complete response rates were 37.4% and 41.3% (P = 0.6115) for patients mobilized with cyclophosphamide combined with growth factor and growth factor alone, respectively, and TTPs were 19.9 months and 20.9 months (P = 0.59). In a multivariate analysis for...Continue Reading

References

Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Sep 20, 2000·Mayo Clinic Proceedings·S V RajkumarP R Greipp
Sep 28, 2002·Blood Reviews·Jean-Luc Harousseau, Michel Attal
Nov 15, 2002·International Journal of Hematology·Bart Barlogie, John D Shaughnessy
May 9, 2003·The New England Journal of Medicine·J Anthony ChildUNKNOWN Medical Research Council Adult Leukaemia Working Party
Jun 27, 2003·The New England Journal of Medicine·Paul G RichardsonKenneth C Anderson
Dec 26, 2003·The New England Journal of Medicine·Michel AttalUNKNOWN InterGroupe Francophone du Myélome
Jan 25, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Conor D Collins

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Citations

Jul 3, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Koji KawamuraYoshinobu Kanda
Jan 14, 2009·Bone Marrow Transplantation·W BensingerJ M McCarty
Aug 30, 2011·Bone Marrow Transplantation·Ş M Bakanay, T Demirer
Jul 22, 2014·Bone Marrow Transplantation·A L GarfallE A Stadtmauer
Jun 19, 2008·Bone Marrow Transplantation·Sk KumarMa Gertz
Dec 11, 2007·Leukemia & Lymphoma·Mark R Litzow
Nov 19, 2010·Expert Review of Hematology·Lloyd E Damon, Lauren E Damon
Sep 17, 2011·Pathology·L Bik ToIan D Lewis
Apr 3, 2010·Blood Reviews·David Dingli, S Vincent Rajkumar
Mar 13, 2016·Revista brasileira de hematologia e hemoterapia·Marco Aurélio Salvino, Jefferson Ruiz
Jan 10, 2008·European Journal of Haematology·Esa Jantunen, Taru Kuittinen
Oct 11, 2011·Transfusion·Esa Jantunen, Roberto M Lemoli
Jul 20, 2010·British Journal of Haematology·Morie A Gertz
Oct 29, 2009·American Journal of Hematology·Hideki NakasoneUNKNOWN Kanto Study Group of Cell Therapy
Jun 24, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Hakan GokerYahya Buyukasik
Jan 21, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Dawn SheppardJason Tay
Jun 11, 2011·Clinical Lymphoma, Myeloma & Leukemia·Dennis L CooperStuart E Seropian
Aug 30, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Iskra PusicJohn F DiPersio
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Tomer MarkRuben Niesvizky
Oct 22, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sergio GiraltSteven Devine
Nov 12, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Luciano J CostaShaji Kumar
Aug 13, 2011·Blood·L Bik ToKirsten E Herbert
Jun 2, 2016·Clinical Lymphoma, Myeloma & Leukemia·Dennis L CooperYanyun Wu
Aug 4, 2016·Annals of Hematology·Ville VarmavuoEsa Jantunen
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David DingliMorie A Gertz

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