PMID: 7083726Jul 1, 1982Paper

Cyclophosphamide plasma and cerebrospinal fluid kinetics with and without dimethyl sulfoxide

Clinical Pharmacology and Therapeutics
M J EgorinN R Bachur

Abstract

Ten patients with brain tumors and indwelling ventricular reservoirs were pretreated with 5% to 10% dimethyl sulfoxide (DMSO) (intravenous, oral, or both) and were then treated with 1.0 to 1.25 gm/m2 cyclophosphamide (CYC). All patients were also on anticonvulsants and dexamethasone. CYC and alkylating activity (alk act) in plasma and concomitant ventricular cerebrospinal fluid (CSF) were measured by gas chromatography and p-nitrobenzyl pyridine assay. CYC entered the CSF without difficulty and was lost from CSF more slowly than from plasma. Alk act did not enter CSF as well as did CYC. DMSO did not alter any measured aspect of CYC or alk act disposition. Specifically, it did not alter the CYC plasma half-life (t1/2), CSF t1/2, peak CSF: peak plasma CYC concentration ratio, or the urinary excretion of CYC. DMSO did not alter the plasma t1/2 or urinary excretion of alk act or the peak CSF:peak plasma concentration ratio of alk act. Our data show reduced plasma t1/2 of CYC and increased plasma and urinary alk act. This may reflect tht effect of long-term therapy with anticonvulsants or steroids.

Citations

Aug 25, 2006·Clinical Pharmacokinetics·Susannah MotlClinton F Stewart
Mar 14, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alice MariottiniPaolo A Muraro
Aug 20, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Harold L Atkins, Mark S Freedman
Nov 5, 2005·Oncology Nursing Forum·Catherine JansenJoel Kramer
Jan 1, 1983·Annals of the New York Academy of Sciences·C A ThuningJ Warren
Aug 1, 1988·Acta Paediatrica Japonica; Overseas Edition·N SakuragawaY Miyazato

Related Concepts

Brain Tumor, Recurrent
Cyclophosphamide, (S)-Isomer
Rheumabene
Drug Interactions
Polychemotherapy

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