PMID: 2510313Nov 1, 1989Paper

Cyclophosphamide use in a young woman with antiphospholipid antibodies and recurrent cerebrovascular accident

Southern Medical Journal
M C PerezE Scopelitis

Abstract

We have described a 25-year-old woman with recurrent cerebral thrombosis associated with very high levels of antibodies against phospholipids. Antinuclear antibodies and clinical features of a defined connective tissue disease were absent. Treatment with plasmapheresis, prednisone, intravenous cyclophosphamide, and warfarin was accompanied by disappearance from the serum of the lupus anticoagulant and the biologic false-positive test for syphilis; IgG anticardiolipin antibodies persisted, however, and the patient had a second cerebral thrombosis. Clinical improvement ultimately occurred after the dosage of cyclophosphamide was optimized and the level of IgG anticardiolipin antibody decreased to a level lower than any that has been previously associated with thrombotic complications.

Citations

Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Zhigao HuangRonald F Pfeiffer
Jan 1, 1995·Clinical Reviews in Allergy & Immunology·J C PietteB Wechsler
Nov 18, 2003·The Journal of Clinical Investigation·Amrie C GrammerPeter E Lipsky
Jun 8, 2004·Arthritis Research & Therapy·Amrie C Grammer, Peter E Lipsky
Jun 1, 1994·The American Journal of the Medical Sciences·R D Merrick, M Vernon

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