Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus

The Cochrane Database of Systematic Reviews
V F M TrevisaniA N Atallah

Abstract

Neuropsychiatric involvement in systemic lupus erythematosus is complex and several clinical presentations are related to this disease such as: convulsions, chronic headache, transverse myelitis, vascular brain disease, psychosis and neural cognitive dysfunction. This systematic review is an update of a review performed in 2000. To assess the efficacy and safety of cyclophosphamide and methylprednisolone in the treatment of neuropsychiatric manifestations of systemic lupus erythematosus. We searched EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL) and MEDLINE up to and including May 2005. Additional articles were sought through handsearching in relevant journals. There were no language restrictions. All randomised controlled trials that compared cyclophosphamide to methylprednisolone were included. Patients of any age and gender were included as long as they fulfilled the criterion of the American College of Rheumatology for the diagnosis of systemic lupus erythematosus and presented with any one of the following neuropsychiatric events: convulsions, organic brain syndrome and cranial neuropathy. Outcome measures included the following: a) overall mortality (primary event); b) motor and psychiatric defic...Continue Reading

Citations

Sep 21, 2011·Journal of Neurology·Christopher EcksteinMichael Levy
Dec 14, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Gloria von GeldernKyra Becker
May 14, 2009·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Si-yu ShenHui Cai
Mar 20, 2012·Best Practice & Research. Clinical Rheumatology·Oscar-Danilo Ortega-Hernandez, Yehuda Shoenfeld
May 9, 2012·Pediatric Clinics of North America·Deborah M Levy, Sylvia Kamphuis

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