PMID: 8588232Dec 1, 1995Paper

Cyclosporin A: analytical methodology and factors affecting therapeutic drug monitoring

Therapeutic Drug Monitoring
D W Holt, A Johnston

Abstract

The majority of centres measuring cyclosporine have followed the advice of previous consensus meetings. Although most measurements are made using assays with a high specificity for the parent compound, there are still some between-method differences that can be attributed to methodological variables, such as antibody specificity and assay calibration. With experience of cyclosporine therapeutic drug monitoring (TDM) now spanning 15 years, it would be reasonable to infer that the subject is incapable of growth. However, continued interest in the pharmacokinetics of cyclosporine, the introduction of a new formulation of the drug, and the development of new immunosuppressive agents all combine to emphasise the still incomplete extent of our knowledge in this field.

Citations

Mar 26, 2004·Transplantation Proceedings·A JorgaA Johnston
Apr 16, 2002·Clinical Therapeutics·Barry D KahanAtholl Johnston
Aug 1, 1996·Therapeutic Drug Monitoring·D W HoltA Johnston
Apr 1, 1997·Therapeutic Drug Monitoring·D W Holt, A Johnston
May 8, 1999·British Journal of Clinical Pharmacology·A Johnston, D W Holt
Dec 29, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·H BrozmanováA Jegorov
Jan 11, 2003·Archives of Pathology & Laboratory Medicine·Steven J SoldinUNKNOWN College of American Pathologists Study

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