Cyclosporin A does not affect platelets in children with idiopathic nephrotic syndrome

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Marcin TkaczykMichał Nowicki

Abstract

The immunosuppressive agents administered to maintain the remission of idiopathic nephrotic syndrome (INS) may have a deleterious effect on several cell types. The aim of this study was to analyze platelet activation and reactivity in children with INS treated with cyclosporin A (CyA). The study groups comprised 16 children with remission of INS induced by CyA and 16 children with glucocorticosteroid-induced remission 8 weeks from the onset of INS relapse. Fifteen healthy children served as controls. Surface expression of CD61, CD62P, and CD42b on resting and thrombin-stimulated platelets was analyzed with flow cytometry. No differences between groups were found in CD61, CD62P, and CD42b surface expression, but markers of the coagulation cascade and fibrinolysis or endothelial injury (F1+2 prothrombin fragments, tissue plasminogen activator inhibitor 1) were elevated in patients treated with CyA compared with children on steroids and healthy controls. No correlations between markers of platelet function and CyA concentration were found. We postulate that CyA administration in nephrotic patients causes an activation of thrombinogenesis but does not influence platelet activation and reactivity in INS.

Citations

Oct 1, 1992·European Journal of Pediatrics·T J NeuhausE P Leumann
Jun 1, 1990·The British Journal of Dermatology·J F Borel
Jul 15, 1996·Thrombosis Research·D PawlakM Mysliwiec
Jun 1, 1997·Hypertension·H J OskarssonM T Olivari
Jan 1, 1997·Nephron·J L Barnes
Feb 23, 2000·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A CitakA Nayir
Feb 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J GalleC Wanner
Feb 7, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M G SeikalyR Browne
Jul 13, 2000·Journal of Cardiovascular Pharmacology·F ReisF Teixeira
Dec 29, 2000·Hypertension Research : Official Journal of the Japanese Society of Hypertension·T GomiR Nagao
Nov 20, 2001·Methods and Findings in Experimental and Clinical Pharmacology·R P ShankarS K Garg
Aug 20, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marcin Tkaczyk, Zbigniew Baj
Oct 19, 2002·Clinical Pharmacology and Therapeutics·Jochen GraffJan Gossmann
Nov 20, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·J MalyszkoM Mysliwiec

Related Concepts

Prevalence Studies
SELP gene
Flow Cytometry
ITGB3 gene
Nephrotic Syndrome
Clotting Factor II Assay
ITGB3 protein, human
Platelet Aggregation Measurement
Restasis
Nephrotic Syndrome, Minimal Change

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