PMID: 8447931Mar 1, 1993Paper

Cyclosporin A-induced transient rise in plasma alkaline phosphatase in kidney transplant patients

Transplant International : Official Journal of the European Society for Organ Transplantation
V A BrinerG Thiel

Abstract

In 1981 cyclosporin A (CyA) became available and replaced azathioprine (Aza) as the immunosuppressive agent in kidney transplantation at the University Hospitals in Basel, Switzerland. Patients on CyA and prednisone (CyA/p) therapy frequently demonstrated an isolated rise in bone-derived serum alkaline phosphatase (aP) concentration, but patients on Aza and prednisone (Aza/p) therapy did not. On the basis of long-term aP concentration and using noninvasive means, the present retrospective study was designed to investigate biochemical markers and radiographic signs of bone disease after successful kidney transplantation in patients on Cya/p treatment. Similar investigations were performed in patients on Aza/p and the results were compared. Follow-up examinations included clinical examination, radiography of the hand, and biochemical analysis of serum and urine. In 139 renal transplant patients on CyA/p, aP increased transiently after successful grafting (at transplantation 84 +/- 43 U/l; on day 90, 112 +/- 82 U/l). In 50 patients aP levels were higher at the time of transplantation (120 +/- 80 U/l) and aP peaked after 8 +/- 6 months, at a mean concentration of 242 +/- 103 U/l. In these patients aP concentrations exceeded the nor...Continue Reading

References

Aug 22, 1991·The New England Journal of Medicine·B A JulianL D Quarles
Aug 1, 1990·Kidney International·H Malluche, M C Faugere
May 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·T Cundy, J A Kanis
Jan 1, 1987·American Journal of Nephrology·J G HeafJ R Andersen
Sep 1, 1986·Kidney International·J A DelmezS L Teitelbaum
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S B WarrenG E Friedlaender
Jan 1, 1985·American Journal of Nephrology·P JaegerJ P Bonjour
Oct 15, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·S ScharlaE Mayer

❮ Previous
Next ❯

Citations

Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·V O Van Hoof, M E De Broe
Aug 17, 2006·Pediatrics International : Official Journal of the Japan Pediatric Society·Cigdem ArikanSema Aydogdu
Aug 4, 2006·European Journal of Clinical Investigation·K Kodras, M Haas
Jan 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F-P TillmannG R Hetzel
Apr 1, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Frank-Peter TillmannGerd-Rüdiger Hetzel
Jan 13, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Koichiro YoshimaruTomoaki Taguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Transplant Infectious Disease : an Official Journal of the Transplantation Society
A KorzetsU Gafter
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
E Goffin
© 2021 Meta ULC. All rights reserved