PMID: 6256660Jan 22, 1981Paper

Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein-Barr virus-induced B-cell lines

Nature
A G BirdS Britton

Abstract

Cyclosporin A (CSA) is a fungal metabolite which exerts profound effects on the immune system and has potential as a selective immuno-suppressive agent. Clinical trials with human renal allograft recipients have confirmed this potential but there have been disturbing reports of lymphoma in a significant number of patients. Despite extensive animal studies, the specificity of this drug for human lymphocyte subpopulations is largely unknown. We demonstrate here that in vitro CSA has no apparent effect on Epstein-Barr virus (EBV)-induced B-lymphocyte activation, but totally inhibits the T-cell dependent pokeweed mitogen (PWM) B-cell response. In addition, CSA markedly facilitates the outgrowth of B-lymphoblastoid cell lines from both EBV-infected and non-infected lymphocytes of EBV immune donors cultured in vitro. These results indicate that CSA can interfere with the lymphocytes normally responsible for maintaining the life-long carrier state initiated by primary infection with EBV, allowing outgrowth of the persistently infected cells circulating in the peripheral blood.

References

Aug 1, 1977·The Journal of Experimental Medicine·D A Thorley-LawsonJ L Strominger
Jan 1, 1979·Scandinavian Journal of Immunology·A G Bird, S Britton
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·B M Reedman, G Klein

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Citations

Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·S Barocci, A Nocera
Oct 1, 1984·Agents and Actions·A W ThomsonJ G Simpson
Feb 15, 1988·Biochemical and Biophysical Research Communications·A CerinoG C Astaldi Ricotti
Aug 15, 1986·Clinica Chimica Acta; International Journal of Clinical Chemistry·V M Darley-UsmarH Hamaguchi
Nov 25, 1988·Journal of Immunological Methods·M C McCannB M Kumpel
Aug 18, 1995·Journal of Immunological Methods·M Okano, D T Purtilo
Jan 1, 1984·International Journal of Immunopharmacology·N W BrattigP A Berg
Jan 1, 1992·Toxicology·B Ryffel
Jul 25, 1981·Lancet·S KobayashiA Kumagai
Oct 24, 2001·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M Okano
Jan 1, 1988·Immunology and Cell Biology·A W HohmannJ Bradley
May 16, 1991·The New England Journal of Medicine
Sep 1, 1983·The Journal of Experimental Medicine·A MuraguchiA S Fauci
Nov 1, 1991·AIDS Research and Human Retroviruses·R W van KuykP A Luciw
Jun 1, 1994·AIDS Research and Human Retroviruses·A DegrassiN M Maraldi
Nov 14, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·E OhnishiT Sairenji
Nov 8, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luis Fernando AriasJulia Blanco

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