Cyclosporin A stimulates transcription and procollagen secretion in tubulointerstitial fibroblasts and proximal tubular cells.

Journal of the American Society of Nephrology : JASN
G WolfE G Neilson

Abstract

The brief study described in this report was undertaken to determine whether cyclosporin A had any direct effect on the expression of tubulointerstitial procollagens in cultured renal cells. Our findings indicate that murine tubulointerstitial fibroblasts secreted significantly more procollagen type I after the addition of cyclosporin A, whereas syngeneic proximal tubular cells expressed significantly more types I and IV procollagen after cyclosporin stimulation. These increases in procollagen gene product correlated concordantly with changes in the levels of cytoplasmic mRNA with procollagen-specific cDNA probes. Transfection of these fibroblasts and proximal tubular cells with chimeric gene constructs containing enhancer/promoter elements for alpha2(I) and alpha 1(IV) procollagen linked to a chloramphenicol acetyltransferase reporter gene indicates that the stimulatory effect of cyclosporin on procollagen expression depends, at least to some extent, on an increase in transcriptional activity.

Citations

Nov 26, 2003·Journal of the American Society of Nephrology : JASN·Anaïs TendronThierry Gilbert
Feb 29, 2020·Prilozi·Theodoros NtriniasDimitrios S Goumenos
Nov 24, 1999·Pediatric Transplantation·P C GrimmD N Rush
Aug 22, 1994·FEBS Letters·L PaslaruM Morange
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hans-Joachim AndersDetlef Schlöndorff
Jan 27, 2004·The Journal of Biological Chemistry·Jennifer L GoochHanna E Abboud
Jul 23, 2003·Journal of the American Society of Nephrology : JASN·Rene C BakkerLeendert C Paul
Dec 1, 1996·Cell Biology and Toxicology·C Merlet-BénichouE Moreau
Aug 1, 1995·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N HackK L Skorecki
Feb 1, 1996·Kidney International·J Egido
Jul 1, 1997·Kidney International·D B Lee
Jul 1, 1992·Kidney International·K L SkoreckiR W Schrier
Sep 12, 2001·Current Hypertension Reports·V SchwengerE Ritz
Aug 28, 2007·Biochemical and Biophysical Research Communications·Scott L Cobbs, Jennifer L Gooch
Feb 9, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Samuel J GhilardiAllyson E Sgro
Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C K AbrassC L Davis
Jul 1, 1997·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F S ShihabW M Bennett
Feb 17, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Maarten NaesensMinnie Sarwal
Sep 26, 2009·Journal of Cellular and Molecular Medicine·Ramesh N ReddyJennifer L Gooch
Oct 29, 2004·The American Journal of Pathology·Jennifer L GoochJeffrey L Barnes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.