Cyclosporin a treatment is able to revert the decrease in circulating GH and IGF-I and the increase in IGFBPs induced by adjuvant arthritis

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
L SotoA López-Calderón

Abstract

The aim of this study was to find out whether cyclosporin A administration is able to revert the decrease in circulating growth hormone (GH) and insulin-like growth factor-I (IGF-I) and the increase in IGF-binding proteins (IGFBPs) levels caused by adjuvant-induced arthritis in rats. Male Sprague-Dawley rats were intradermically injected with Freund's adjuvant or vehicle. Fourteen days later, rats were randomly divided into two groups - one injected with cyclosporin (15 mg/kg) and the other with vehicle from day 16 to 23 after adjuvant injection. Arthritis decreased body weight gain and serum concentrations of GH. Cyclosporin administration to arthritic rats prevented both effects, whereas cyclosporin had no effect in control rats. Arthritis decreased serum concentrations of IGF-I (p < 0.01), but increased IGFBPs. Cyclosporin administration increased circulating IGF-I, and there was a negative correlation between circulating IGF-I and arthritis index scores in arthritic rats injected with cyclosporin (p < 0.05). Cyclosporin treatment did not alter serum IGFBPs levels in control rats, whereas cyclosporin administration normalised IGFBPs in arthritic rats. These results indicate that the effects of cyclosporin administration on t...Continue Reading

Citations

Nov 23, 2006·Neurosurgical Focus·Joseph C MaroonNathan A Ross
Aug 3, 2006·Journal of Clinical Pharmacy and Therapeutics·A Damasiewicz-BodzekB Suwała-Jurczyk
Jul 31, 2012·Scandinavian Journal of Rheumatology·G S DhaunsiM Z Haider
Feb 28, 2009·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·E del PozoP Mullis
Feb 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Miriam GranadoAsunción López-Calderón
Jun 4, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·María López-MenduiñaAsunción López-Calderón
May 10, 2018·Frontiers in Physiology·Sandra Pérez-BaosGabriel Herrero-Beaumont
Feb 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Estíbaliz CastilleroAsunción López-Calderón

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