Cyclosporin for the treatment of severe inflammatory bowel disease

Alimentary Pharmacology & Therapeutics
K Baker, D P Jewell

Abstract

A pilot study was performed to assess the role of cyclosporin in the management of severe inflammatory bowel disease. Twelve patients with Crohn's disease and 12 with ulcerative colitis were admitted to hospital with a severe attack. They were treated with an intravenous regimen of corticosteroids for 5 days followed by oral therapy. In addition, they received a 6-week course of oral cyclosporin, initially 15 mg kg-1 day-1 reduced to 7.5 mg kg-1 day-1. In comparison with historical controls, the addition of cyclosporin to standard corticosteroid therapy appeared to have no benefit. Adverse effects were common but minor. The expression of Class II molecules on the inflamed epithelium was rapidly reversed by cyclosporin therapy which may indicate a potential therapeutic benefit over longer periods of time.

References

Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·D P Jewell, C Patel
Feb 1, 1987·Alimentary Pharmacology & Therapeutics·M C Allison, R E Pounder
Mar 1, 1987·Journal of Clinical Pathology·G B McDonald, D P Jewell
Apr 1, 1986·Journal of Clinical Gastroenterology·H A ShepherdD P Jewell
Jan 1, 1985·Annual Review of Immunology·E M Shevach
Dec 14, 1974·British Medical Journal·D P Jewell, S C Truelove
Jun 1, 1974·Gut·F T De DombalJ C Goligher
Apr 21, 1984·Lancet·M C Allison, R E Pounder
Jun 2, 1984·Lancet·P A BianchiT Ranzi
Dec 1, 1984·Lancet·S GuptaH J Hodgson
Dec 1, 1982·The Journal of Experimental Medicine·A N Barclay, D W Mason
Oct 29, 1955·British Medical Journal·S C TRUELOVE, L J WITTS

❮ Previous
Next ❯

Citations

Apr 1, 1993·Alimentary Pharmacology & Therapeutics·R A Kozarek
Feb 24, 2001·Alimentary Pharmacology & Therapeutics·E IerardiA Francavilla
Oct 13, 2001·Diseases of the Colon and Rectum·G M HydeN J Mortensen
Jun 16, 2011·Inflammatory Bowel Diseases·David BeddyJohn H Pemberton
Mar 1, 1995·Digestive Diseases and Sciences·A ScalziniL Sueri
Oct 1, 1993·Alimentary Pharmacology & Therapeutics·M Carpani de Kaski, H J Hodgson
Mar 27, 2003·Inflammatory Bowel Diseases·Johanna C EscherRichard J Grand
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G M HydeB F Warren
Aug 1, 1993·Scandinavian Journal of Gastroenterology·T A WinterD P Jewell
May 3, 2000·Alimentary Pharmacology & Therapeutics·S J Bell, M A Kamm
Jan 14, 2005·European Journal of Gastroenterology & Hepatology·Simon CampbellDerek Jewell
Aug 1, 1991·Alimentary Pharmacology & Therapeutics·H J Hodgson
Sep 1, 1994·Archives of Disease in Childhood·S NichollsJ A Walker-Smith
Apr 23, 2005·The Cochrane Database of Systematic Reviews·J W D McDonaldJ K Macdonald

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.