PMID: 2873396Jul 19, 1986

Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial

Gilles FeutrenA Lallemand


In a double-blind trial 122 patients aged 15-40 years with insulin-dependent diabetes of recent onset were randomly assigned to cyclosporin 7.5 mg/kg per day or placebo. At the sixth month 25.4% of the cyclosporin group and 18.6% of the placebo group were in complete remission (not a significant difference). Treatment was continued in those patients with complete or partial remission (insulin requirement less than 0.25 U/kg per day) and 106 patients were followed to nine months, at which stage 24.1% of the original cyclosporin group and 5.8% of the original placebo group were in complete remission (p less than 0.01). For those patients whose whole-blood trough cyclosporin levels in the first three months averaged 300 ng/ml or more, the rates of complete remission at six and nine months were 37.5% and 37%. The rates of partial remission were also higher in the cyclosporin group and at six months the rate of complete or partial remission was 46% in the whole cyclosporin group and 65.6% in those with an average blood level exceeding 300 ng/ml in the first three months, versus 28.8% in the placebo group. The principal side-effect of cyclosporin was a modest and reversible increase in plasma creatinine. These results indicate that c...Continue Reading


Feb 16, 1985·Lancet·V A Koivisto, R Pelkonen
Apr 1, 1986·Diabetologia·Y MoriM Nishimura
Sep 12, 1985·The New England Journal of Medicine·F L CullerJ C Roth
Dec 1, 1985·Diabetes·J F YaleE B Marliss
Jan 1, 1983·Lancet·A LaupacisP Thibert
Jul 1, 1984·Diabetologia·A AnderssonA Schnell
Nov 1, 1984·Annals of Internal Medicine·D J CohenT B Strom
Oct 1, 1984·The American Journal of Medicine·A PalestineC C Chan


Mar 1, 1991·Diabetes/metabolism Reviews·D AndreaniP Pozzilli
Dec 1, 1993·Diabetes/metabolism Reviews·B VialettesL Hermitte
Dec 1, 1993·Diabetes/metabolism Reviews·T Mandrup-PoulsenJ Nerup
Sep 1, 1996·Diabetologia·T Mandrup-Poulsen
Jan 1, 1992·Acta Diabetologica·V A KoivistoO Ylikorkala
Mar 1, 1990·Journal of Clinical Immunology·S A Schwartz
Jan 1, 1994·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P MarchettiD W Scharp
Jan 1, 1995·Folia Microbiologica·Z Rehácek
Jan 1, 1988·Immunologic Research·G N Gaulton, J F Markmann
Jul 25, 2012·Clinical and Experimental Medicine·Jan Novak, Lucie Novakova
Jul 22, 2004·Current Diabetes Reports·Mariela Glandt, K C Herold
Jan 1, 1991·International Journal of Immunopharmacology·F NicolettiL Mughini
Mar 16, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Ken T CoppietersMatthias von Herrath
Jun 4, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Anastasia G DaifotisK C Herold
Nov 8, 1986·Lancet·R AssanK J Lafferty
Mar 14, 1987·Lancet·J DupreM Gent
Apr 16, 1988·Lancet·A C TarnEdwin A M Gale
Sep 16, 1989·Lancet·H KolbC R Stiller
Jun 1, 1991·Baillière's Clinical Endocrinology and Metabolism·P J Bingley, Edwin A M Gale
Sep 7, 2001·Current Opinion in Immunology·J F Bach
Dec 27, 2011·Nano Letters·Kaustabh GhoshDonald E Ingber
May 31, 2002·The New England Journal of Medicine·Edwin A M Gale
Oct 10, 2008·The New England Journal of Medicine·Denise L Faustman
Jun 24, 2005·The New England Journal of Medicine·B KeymeulenLucienne Chatenoud
Feb 3, 2012·The New England Journal of Medicine·Johnny LudvigssonSabine Baron
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A BrodW Riley
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod
Sep 7, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Staley A Brod
Jun 29, 2013·Diabetes Technology & Therapeutics·J S Skyler, Alberto Pugliese
Nov 1, 1991·Journal of Gastroenterology and Hepatology·Y I WangK J Lafferty
Jun 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·B Feldt-RasmussenP P Leyssac
Sep 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·B VialettesF Elgrably
Jan 1, 1994·Diabetic Medicine : a Journal of the British Diabetic Association·P PozzilliL Lucentini
Jan 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A A KallanB O Roep
Apr 1, 1989·Archives of Disease in Childhood·D I Johnston
Mar 1, 1993·Annals of the Rheumatic Diseases·H Gaston
Mar 24, 1998·Annual Review of Medicine·Peter A Gottlieb, G S Eisenbarth
Jul 26, 2011·Clinical & Developmental Immunology·Brett PhillipsNick Giannoukakis
Mar 1, 1987·The Journal of Clinical Investigation·S BaekkeskovF Lindgren
Jul 19, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kathleen M Gillespie
May 12, 2007·The Review of Diabetic Studies : RDS·Lucienne Chatenoud, Jean-François Bach
Jan 1, 2012·The Review of Diabetic Studies : RDS·Ken T CoppietersMatthias von Herrath
Feb 14, 2013·The Review of Diabetic Studies : RDS·Benno WeigmannCarolin Daniel
May 1, 2007·Regenerative Medicine·K Ananda KrishnaKrs Sambasiva Rao
Nov 8, 2011·Immunotherapy·Ben SprangersChantal Mathieu
Aug 19, 2011·Indian Journal of Endocrinology and Metabolism·Vishvas Garg
Nov 15, 2012·Immunotherapy·Nick Giannoukakis, Massimo Trucco
Aug 16, 2006·Clinical and Experimental Immunology·B Z AlizadehDIABMARKER Study Group
Mar 22, 2012·Autoimmunity·Eliana Mariño, Shane T Grey
Mar 17, 2011·Expert Opinion on Biological Therapy·Pieter Gillard, Chantal Mathieu
Jun 1, 1987·Acta Paediatrica Japonica; Overseas Edition·N MaclarenW Riley
Jun 1, 1989·British Journal of Haematology·E M LeonardN S Young
Dec 1, 1986·Immunological Reviews·G F BottazzoR Pujol-Borrell
Apr 1, 1993·Diabetes Research and Clinical Practice·A GodayR Gomis
Jan 1, 1990·Clinical Immunology and Immunopathology·M BlankY Shoenfeld
Dec 1, 1987·The Journal of Pediatrics·Gilles FeutrenJ F Bach
Sep 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·P PozzilliD Andreani
Jan 10, 2008·Trends in Immunology·Dieter KabelitzLucienne Chatenoud
Sep 1, 1989·Clinical Immunology and Immunopathology·J ZielasekG S Eisenbarth
Sep 1, 1987·Pediatric Annals·J S Skyler, A Rabinovitch
Oct 13, 2017·Current Diabetes Reports·Laura M JacobsenTodd M Brusko
Dec 7, 2002·Diabetes/metabolism Research and Reviews·R AssanJean-François Bach
Dec 21, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Matthias von HerrathDamien Bresson
Jul 21, 2007·Nature Reviews. Immunology·Lucienne Chatenoud, Jeffrey A Bluestone
Nov 29, 2008·Clinical and Experimental Immunology·J M LawsonT I M Tree
Nov 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·P Pozzilli
Jan 6, 2009·Annals of the New York Academy of Sciences·J S SkylerType 1 Diabetes TrialNet Study Group
Feb 23, 2010·Nature Reviews. Endocrinology·Lucienne Chatenoud
Dec 15, 1986·Klinische Wochenschrift·U Bicker, K H Usadel
May 25, 2010·Clinical and Experimental Immunology·G Mukherjee, T P Dilorenzo
May 5, 2010·Acta Diabetologica·Douglas O SobelVal Abbassi
Nov 11, 2005·American Journal of Therapeutics·Theresa AlyG S Eisenbarth
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·M Abel, M Krokowski
Mar 30, 2007·Clinical Pharmacology and Therapeutics·J S Skyler
Jun 2, 2011·Nature Reviews. Drug Discovery·Frank Waldron-Lynch, K C Herold
Sep 1, 2011·Nature Reviews. Endocrinology·Lucienne Chatenoud
May 1, 2010·Nature·Jeffrey A BluestoneG S Eisenbarth
Oct 13, 2011·British Journal of Clinical Pharmacology·Lara Aygen ØzbayKaj Anker Jørgensen
Jan 4, 2012·Annals of the New York Academy of Sciences·Mary Pat GallagherCarla J Greenbaum
Mar 25, 2016·World Journal of Transplantation·Adrian D HibberdPatrick Mcelduff
Jun 16, 2005·QJM : Monthly Journal of the Association of Physicians·P NarendranS Fourlanos
Dec 21, 1989·The New England Journal of Medicine·B D Kahan
Jun 1, 1989·British Journal of Clinical Pharmacology·L VernilletM Olmer
Sep 8, 1988·The New England Journal of Medicine·J SilversteinS Johnson
Mar 17, 1988·The New England Journal of Medicine·P F BougneresJ L Chaussain
Sep 15, 1987·Hospital Practice·G S Eisenbarth
Sep 8, 1988·The New England Journal of Medicine
Oct 1, 1987·Diabetes/metabolism Reviews·J S Skyler
Jul 1, 1994·Clinical and Experimental Immunology·P SaïE Gouin
Jan 1, 1997·Autoimmunity·J S PetersenT Dyrberg
Dec 18, 2002·Experimental Biology and Medicine·Staley A Brod
Oct 27, 2014·Current Diabetes Reports·Michelle RosenzwajgDavid Klatzmann
Jul 21, 2015·The Journal of Clinical Investigation·Mark R RigbyMario R Ehlers
Dec 10, 2015·European Journal of Immunology·Lucienne Chatenoud
Oct 8, 2015·Paediatric and Perinatal Epidemiology·Jasveer VirkJørn Olsen
Dec 5, 2013·Diabetes/metabolism Research and Reviews·Johnny LudvigssonClinical GAD-Study Group in Sweden
May 25, 2015·Current Diabetes Reports·Per-Ola CarlssonKatarina Le Blanc
May 24, 2017·Current Diabetes Reports·Robert N Bone, Carmella Evans-Molina
Mar 17, 1988·The New England Journal of Medicine·K C Herold, A H Rubenstein
Aug 16, 2016·Current Diabetes Reports·Scott J PillaNestoras N Mathioudakis
Mar 1, 1996·Journal of Pediatric Endocrinology & Metabolism : JPEM·P W Mathieson
May 1, 1987·Postgraduate Medicine·P G Colman, G S Eisenbarth
May 2, 2019·World Journal of Diabetes·Spyridon N KarrasKalliopi Kotsa
Nov 30, 1993·Annals of the New York Academy of Sciences·J F Bach
Dec 17, 2019·Cell Metabolism·Jeremy T WarshauerMark S Anderson

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