Cyclosporine A and adverse effects on organs: histochemical studies

Progress in Histochemistry and Cytochemistry
Rita Rezzani

Abstract

The discovery that cyclosporine A (CsA) was a powerful immunosuppressant had a significant impact on transplant medicine. Its molecular mechanism of action has been well defined in T cells and involved inhibition of critical signalling pathways that regulated T-cell activation. In fact, CsA inhibited calcineurin phosphatase activity and thereby activation of the transcription factor nuclear factor of activated T cells. Over 10 years, its use is limited by side effects, determining nephro- and hepatotoxicity, gingival hypertrophy, tremor and increased blood pressure. These negative effects have been identified through morphological alterations and/or clinical parameters, i.e. variation in glomerular filtration rate for nephrotoxicity. Nevertheless, CsA remains a therapeutic valuable agent and it is normally utilized into clinical practice even if different dose adjustments or discontinuations in a significant percentage of patients must be used. This review focuses on the following topics: mechanisms of action and drug metabolism, interactions with other drugs, clinical and morphological evaluation of toxic effects on target organs. In particular, the morphological evaluation of negative effects has been considered reporting lig...Continue Reading

References

Jul 1, 1976·Agents and Actions·J F BorelH Stähelin
Apr 1, 1992·Immunology Today·S L Schreiber, G R Crabtree
Aug 1, 1992·International Journal of Immunopharmacology·E J de WaalH Van Loveren
Jan 1, 1992·British Journal of Clinical Pharmacology·J DreweT Kissel
Jan 1, 1992·Journal of Comparative Pathology·Z MilićevićN M Milićević
Jun 1, 1992·The British Journal of Dermatology·M J Mihatsch, K Wolff
Jan 1, 1991·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K HirakawaK Kuriyama
Jan 1, 1991·American Journal of Nephrology·K Wenzel-SeifertF Keller
Feb 1, 1991·Cellular Immunology·W E Beschorner, O A Armas
Oct 1, 1990·Clinical Pharmacokinetics·G C Yee, T R McGuire
Nov 1, 1990·Therapeutic Drug Monitoring·K R CopelandR W Yatscoff
Dec 1, 1990·Journal of the American Academy of Dermatology·P B Watkins
Oct 19, 1989·The New England Journal of Medicine·J ShowstackO Salvatierra
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N M MilićevićM Colić
May 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M TakeyaK Takahashi
Jan 1, 1989·Annual Review of Pharmacology and Toxicology·F P Guengerich
Sep 1, 1989·Transplantation·U KunzendorfG Offermann
Dec 21, 1989·The New England Journal of Medicine·B D Kahan
Aug 1, 1989·Transplantation·L FamiglioR Fisher
Jun 1, 1988·Transplantation·D P VogtT A Broughan
Aug 1, 1988·Kidney International·T StrzeleckiM Menon
May 8, 1986·The New England Journal of Medicine·UNKNOWN Canadian Multicentre Transplant Study Group
May 1, 1988·Neurologic Clinics·A J MartinezA A Faris
Aug 1, 1988·Clinical Neuropharmacology·G Belendiuk, S Solch
Nov 1, 1987·Journal of Clinical Pharmacology·A VellodiK Hugh-Jones
Mar 17, 1988·The New England Journal of Medicine·P F BougneresJ L Chaussain
Oct 1, 1988·Mayo Clinic Proceedings·P C de Groen
Jan 7, 1988·The New England Journal of Medicine·C EastJ A Farmer
Apr 1, 1988·Transplantation·W E BeschornerG W Santos
Feb 1, 1988·Kidney International·B D MyersN S Coplon
Oct 1, 1987·The New England Journal of Medicine·P C de GroenR A Krom
Sep 1, 1987·European Journal of Immunology·V F QuesniauxM H Van Regenmortel
Aug 1, 1988·The American Journal of Medicine·W M Bennett, G A Porter

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Citations

Nov 26, 2013·Archives of Pharmacal Research·Golam KibriaHideyoshi Harashima
Jun 15, 2005·International Immunopharmacology·Rita RezzaniRossella Bianchi
Oct 24, 2009·Nature Reviews. Cancer·Maria Mancini, Alex Toker
Apr 12, 2011·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Ralph NivenHoward Raff
Oct 16, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hyun Ho RyuByung Chul Shin
Feb 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Helen G Haggerty, Stanley J Proctor
Mar 11, 2009·Molecular and Cellular Biology·Sohum MehtaKyle W Cunningham
Feb 15, 2013·BMC Complementary and Alternative Medicine·Karine M FreitasHeidi Dolder
Dec 11, 2013·Environmental Toxicology and Pharmacology·Deepa K IngawaleSuresh R Naik
Aug 2, 2014·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Yehui ChenZhiwei Zhang
Aug 31, 2014·Bioinformatics·Gang HuLukasz Kurgan
Mar 16, 2005·Journal of the American Animal Hospital Association·Rosanna Marsella
Jun 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Barbara BuffoliRita Rezzani
Jun 25, 2009·Expert Opinion on Drug Safety·Aaron M CookByron Young
May 19, 2009·Expert Opinion on Pharmacotherapy·Jordi Díaz-ManeraIsabel Illa
Oct 20, 2010·Drug and Chemical Toxicology·Elife ErarslanTuncay Delibasi
Jan 31, 2012·Biochemical Pharmacology·Che-Ming Jack Hu, Liangfang Zhang
Mar 30, 2010·Revue neurologique·S BouomraniS Mahjoub
Mar 2, 2010·Chemico-biological Interactions·Ana Elisa BöhmerDiogo Onofre Souza
Jan 13, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Joseph W RossanoWilliam J Dreyer
Jun 28, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Meltem KurusAli Otlu
Jun 17, 2008·Progress in Histochemistry and Cytochemistry·Rita RezzaniLuigi Fabrizio Rodella
Nov 15, 2011·Journal of Proteomics·Ruby P PonnuduraiShantanu Sengupta
Dec 4, 2015·Canadian Journal of Physiology and Pharmacology·Nagla A El-Sherbeeny, Manar A Nader
Apr 6, 2007·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Hisako FujimuraWataru Toriumi
Oct 2, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Manfred HeckingMarcus D Säemann
Sep 14, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Maha Al-MohayaSook-Bin Woo
Oct 13, 2007·Stem Cells·Veronika S UrbánFerenc Uher
Sep 26, 2008·Basic & Clinical Pharmacology & Toxicology·Abdurrauf YüceAli Osman Ceribaşi
Oct 12, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Zohreh Mostafavi-PourMahmood Vessal
Aug 7, 2013·Dermatologic Therapy·Jillian Wong MillsopJenny E Murase
Aug 16, 2012·Phytotherapy Research : PTR·Na WeiYu-Yang Zhang
Aug 19, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Serdar NasirMaria Siemionow
Apr 29, 2006·International Immunopharmacology·Rita RezzaniRossella Bianchi
Jan 24, 2006·International Immunopharmacology·Camila Eduardo MarinhoPaulo Flavio Silveira

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