Cyclosporine A mediates fibroproliferation through epithelial cells

Transplantation
Katrin HostettlerPeter Borger

Abstract

Obliterative bronchiolitis (OB) is the major cause of morbidity and mortality after lung transplantation. The potential role of immunosuppressive drugs in the development of OB is uncertain, but there are limited data indicating that cyclosporine A (CsA) may have a direct fibrogenic effect on various human cell types. Epithelium-fibroblast interactions have been suggested to play a crucial role in the course of fibroproliferation, which is a major feature of OB. We studied the effect of CsA and FK506 on primary human lung fibroblast proliferation in a human epithelial-fibroblast interactive model. Clinically relevant concentrations of CsA (0.1-1 microg/mL) and FK506 (0.001-0.01 microg/mL) did not affect fibroblast proliferation in monocultures. Conditioned medium (CM) from untreated epithelial cells (Calu-3) stimulated fibroblast proliferation. CM from FK506-treated (0.001-0.1 microg/mL) epithelial cells had no significant additive effect on fibroblast proliferation compared with CM of untreated epithelial cells. In contrast, CM obtained from epithelial cells treated with 0.1 microg/mL CsA significantly enhanced fibroblast proliferation compared with CM of untreated epithelial cells. This proliferative effect of 0.1 microg/mL C...Continue Reading

References

Sep 1, 1995·The Annals of Thoracic Surgery·R J KeenanB P Griffith
Jul 1, 1995·American Journal of Respiratory Cell and Molecular Biology·I CaniggiaM Post
Aug 1, 1995·Cell and Tissue Research·J S ErjefältC G Persson
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·A T IaconoB P Griffith
Jul 1, 1996·In Vitro Cellular & Developmental Biology. Animal·T MioS I Rennard
Jan 13, 1998·The European Respiratory Journal·N Briffa, R E Morris
Oct 21, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·A El-GamelI V Hutchinson
Feb 12, 2000·The Journal of Allergy and Clinical Immunology·S T HolgateJ L Lordan
Apr 25, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M G AtturA R Amin
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B B MooreG B Toews
Feb 15, 2001·Annals of Internal Medicine·M SelmanUNKNOWN American College of Chest Physicians
May 10, 2001·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H TreedeUNKNOWN Munich and Vienna Lung Transplant Group
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·T PanJ M Shannon
Aug 21, 2002·American Journal of Respiratory and Critical Care Medicine·Marc Estenne, Marshall I Hertz
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bethany B MooreGalen B Toews
Sep 27, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Shigenobu YazawaTamao Ono
Nov 19, 2003·Biochemical and Biophysical Research Communications·Hengming Ke, Qing Huai

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Citations

Oct 31, 2009·American Journal of Respiratory and Critical Care Medicine·Janette K BurgessBrian G Oliver
May 17, 2014·Journal of Cardiovascular Translational Research·S J Jansen Of LorkeersS A J Chamuleau
Mar 5, 2016·Journal of Toxicology·Said Said ElshamaHosam-Eldin Hussein Osman
Jun 1, 2011·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Annika Andersson-SjölandGunilla Westergren-Thorsson
Jan 14, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jun ZhongMichael Roth
Oct 11, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Isabel P NeuringerScott H Randell
May 28, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K E HostettlerP Borger
Sep 25, 2012·Journal of Cellular and Molecular Medicine·Markus WeckmannJanette Kay Burgess
Sep 26, 2006·Advanced Drug Delivery Reviews·T E Corcoran
Apr 14, 2017·The European Respiratory Journal·Allan R Glanville
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohiro MurakawaMark R Nicolls

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