Cyclosporine A protects against primary biliary cirrhosis recurrence after liver transplantation.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Aldo J Montano-LozaAndrew L Mason

Abstract

Primary biliary cirrhosis (PBC) reoccurs in a proportion of patients following liver transplantation (LT). The aims of our study were to evaluate the risk factors associated with PBC recurrence and determine whether recurrent disease constitutes a negative predictor for survival. One hundred and eight patients receiving LT for end-stage PBC were studied. Recurrent disease was diagnosed in 28 patients (26%). Probability of recurrent PBC at 5 years was 13% and 29% at 10 years with an overall incidence of 3.97 cases per 100 patient years. By univariate Cox analysis use of tacrolimus (HR 6.28, 95% CI, 2.44-16.11, p < 0.001) and mycophenolate mofetil (HR 5.21, 95% CI, 1.89-14.33, p = 0.001) were associated with higher risk of recurrence; whereas use of cyclosporine A (CsA) and azathioprine were associated with reduced risk of recurrence (HR 0.13, 95% CI 0.05-0.35, p < 0.001 and HR 0.27, 95% CI 0.11-0.64, p = 0.003, respectively). In the multivariate Cox analysis, only CsA was independently associated with protection against recurrence (HR 0.17, 95% CI 0.06-0.71, p = 0.02). Five-year probability of survival was 83% and 96%, in patients without and with recurrence (log-rank test, p = 0.3). Although PBC transplant recipients receiving ...Continue Reading

References

Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E R DicksonA Langworthy
Jan 7, 1982·The New England Journal of Medicine·J NeubergerR Williams
Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Van de WaterM E Gershwin
Jul 27, 1999·European Journal of Gastroenterology & Hepatology·E B Haagsma
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R F Liermann GarciaJ Neuberger
Jun 5, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James Neuberger
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josh LevitskyHelen S Te
Jul 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lizhe XuAndrew Mason
Jul 10, 2003·Autoimmunity Reviews·James Neuberger
Mar 30, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James NeubergerPeter Nightingale
Sep 27, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jennifer E GuyMarion G Peters
Jul 11, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V C McAlisterL L Gluud
Feb 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Patrick S KamathUNKNOWN Advanced Liver Disease Study Group
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Helen RobertsonAlastair D Burt
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shawn Wasilenko, Andrew L Mason
Sep 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Phunchai CharatcharoenwitthayaRussell H Wiesner
Dec 22, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M Eric Gershwin, Ian R Mackay
May 22, 2009·The New England Journal of Medicine·Gideon M HirschfieldKatherine A Siminovitch
Jul 30, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Shawn T WasilenkoAndrew L Mason

❮ Previous
Next ❯

Citations

Oct 29, 2011·Clinics in Liver Disease·Flavia MendesCynthia Levy
Jun 29, 2010·Gastroentérologie Clinique Et Biologique·A L Mason, G Zhang
Feb 2, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Monica El-MasrySammy Saab
Sep 20, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Junichi KanekoNorihiro Kokudo
Sep 17, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andrew L Mason, Aldo J Montano-Loza
Oct 24, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroto EgawaHirohito Tsubouchi
Aug 19, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John O'Grady
Jun 21, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo J Montano-LozaAndrew L Mason
Nov 14, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Rahima A BhanjiAldo J Montano-Loza
Jan 9, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·UNKNOWN Working Subgroup (English version) for Clinical Practice Guidelines for Primary Biliary Cirrhosis
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Jawad A IlyasJohn M Vierling
Oct 31, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Guido StirnimannAldo J Montano-Loza
Jan 6, 2018·Scandinavian Journal of Gastroenterology·Lina LindströmAnnika Bergquist
May 25, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Aldo J Montano-LozaAndrew L Mason
Apr 28, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Andrew L Mason, Katherine A Siminovitch
Dec 14, 2016·Alimentary Pharmacology & Therapeutics·A J Montano-LozaA L Mason
Jul 15, 2017·Current Hepatology Reports·Antonio Molinaro, Hanns-Ulrich Marschall
Feb 7, 2018·Hepatology Communications·Aldo J Montano-Loza, Andrew L Mason
Dec 4, 2020·Clinical and Molecular Hepatology·Atsushi Tanaka
Jan 1, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Xiaocheng LiHuapeng Lin
Oct 23, 2018·Best Practice & Research. Clinical Gastroenterology·Andrew L Mason
Nov 14, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mark R PedersenMarlyn J Mayo
Jul 17, 2021·Gut·Palak J Trivedi, Gideon M Hirschfield
Apr 11, 2020·Journal of Hepatology·Christophe CorpechotUNKNOWN Global PBC Study Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Phunchai CharatcharoenwitthayaR Wiesner
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Jean-Charles Duclos-Vallee, M Sebagh
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Pinelopi ManousouAndrew K Burroughs
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
James NeubergerPeter Nightingale
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Manjushree GautamVijayan Balan
© 2021 Meta ULC. All rights reserved