Cyclosporine A versus tacrolimus monotherapy. Comparison on bile lipids in the first 3 months after liver transplant in humans

Transplant International : Official Journal of the European Society for Organ Transplantation
Leonardo BaiocchiGiuseppe Tisone

Abstract

Biliary lipids output is reduced after liver transplantation and tends to normalize thereafter. Cyclosporine A (CyA) is reported to interfere with the normal bile-restoring process after liver grafting, but data are inconclusive, in particular regarding the comparison with the other widely used calcineurin inhibitor tacrolimus (TCR). Furthermore, previous researches were conducted in patients taking multiple immunosuppressive therapies and with a short follow up. In this study we readdressed this issue by comparing biliary lipids in the first 3 months after liver transplant, in 20 patients randomized to receive immunosuppression with CyA or TCR monotherapy. Bile samples, harvested through a T-tube at days 1, 3, 7, 15, 30, 60 and 90 were assessed for cholesterol, phospholipids, and total and individual concentrations of bile acids (BA). Liver and kidney function tests were evaluated as well. We found no differences between CyA and TCR in biochemical findings or in total biliary BAs, cholesterol, and phospholipids. However, CyA-treated patients showed lower levels of glycochenodeoxycholic acid at day 15, compared to those treated with TCR (P < 0.04). This difference normalized thereafter, without any biochemical or clinical effec...Continue Reading

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Citations

Aug 6, 2014·International Journal of Molecular Sciences·Katharina StauferLili Kazemi-Shirazi
Sep 12, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G OrlandoG Tisone
Aug 6, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Shoichiro MukaiHideki Ohdan
Apr 1, 2017·The Cochrane Database of Systematic Reviews·Manuel Rodríguez-PerálvarezKurinchi Selvan Gurusamy
Apr 26, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Leonardo BaiocchiMario Angelico
Oct 29, 2010·Expert Review of Clinical Immunology·Giuseppe Orlando
Oct 25, 2012·Clinical Oral Implants Research·Irena SailerDavid Schneider

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