PMID: 11907192Mar 22, 2002Paper

Cyclosporine adversely affects baroreflexes via inhibition of testosterone modulation of cardiac vagal control

The Journal of Pharmacology and Experimental Therapeutics
M M El-MasFouad M Sharabi

Abstract

Previous studies have shown that the immunosuppressant drug cyclosporine A attenuates arterial baroreceptor function. This study investigated whether the modulatory effect of cyclosporine on baroreceptor function involves inhibition of the baroreflex-facilitatory effect of testosterone. The role of cardiac autonomic control in cyclosporine-testosterone baroreflex interaction was also investigated. Baroreflex curves relating bradycardic responses to increments in blood pressure evoked by phenylephrine were constructed in conscious, sham-operated, castrated rats and in testosterone-replaced castrated (CAS + T) rats in the absence and presence of cyclosporine. The slopes of the curves were taken as an index of the baroreflex sensitivity (BRS). Short-term (11-13 days) cyclosporine treatment or castration reduced plasma testosterone levels and caused similar attenuation of the reflex bradycardia, as indicated by the significantly smaller BRS compared with sham-operated values (-0.97 +/- 0.07, -0.86 +/- 0.06, and -1.47 +/- 0.10 beats/min/mm Hg, respectively). The notion that androgens facilitate baroreflexes is further confirmed by the observation that testosterone replacement of castrated rats restored plasma testosterone and BRS to...Continue Reading

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Citations

Mar 17, 2005·Cardiovascular Drugs and Therapy·Amal G Omar, Mahmoud M El-Mas
Apr 16, 2004·Journal of Cardiovascular Pharmacology·Mahmoud M El-MasFouad M Sharabi
Jun 21, 2008·Clinical and Experimental Pharmacology & Physiology·Sahar M El-GowillyMahmoud M El-Mas
Feb 8, 2006·Canadian Journal of Physiology and Pharmacology·Mahmoud M El-MasFouad M Sharabi
Jul 6, 2006·Clinical and Experimental Hypertension : CHE·Etain Tansey, Christopher Bell
Oct 3, 2012·The Journal of Physiology·Megan M Wenner, Nina S Stachenfeld
Apr 16, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jerzy Krzysztof WraniczWojciech Zareba
May 23, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Osama F HarrazMahmoud M El-Mas
Sep 15, 2012·European Journal of Pharmacology·Mahmoud M El-MasAmal G Omar
Nov 29, 2014·Naunyn-Schmiedeberg's Archives of Pharmacology·Hanan M El-Gowelli, Mahmoud M El-Mas
Apr 25, 2018·Journal of Cardiovascular Pharmacology·Amany E El-NaggarFouad M Sharabi
May 24, 2012·The Journal of Pharmacology and Experimental Therapeutics·Mahmoud M El-MasMai M Helmy
Mar 11, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hossam A Shaltout, Abdel A Abdel-Rahman
Nov 12, 2017·Biochemical and Biophysical Research Communications·Hany M El-Bassossy, Basma G Eid
May 28, 2021·Clinical and Experimental Pharmacology & Physiology·Shrouk S ElzokmMahmoud M El-Mas

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