Cyclosporine-associated leukoencephalopathy in organ transplant recipients: experience of three clinical cases

Transplantation Proceedings
R MuñozF González

Abstract

Leukoencephalopathy is a structural alteration of cerebral white matter mainly involving damage to myelin. Several reports have linked cyclosporine (CsA) with this alteration. The clinical features vary from qualitative alterations of consciousness to neurological deficits. Magnetic resonance imaging (MRI) of the brain demonstrates the damage to the white matter, which is essential for the differential diagnosis. We describe three clinical cases of leukoencephalopathy. The first case is a 43-year-old man received a cadaveric kidney transplant using immunosuppression with of mycophenolate mofetil, prednisone, and CsA. Four months later he developed meningism and bilateral sixth nerve palsy. The second case is a 50-year-old man with a cadaveric kidney transplant received immunosuppressive treatment with azathioprine and prednisone. As a result of gouty arthritis of the ankle, azathioprine was replaced with CsA to allow addition of allopurinol. Two weeks later he developed confusion and personality changes. The third case is a 16-year-old man received a orthotopic liver transplant. Postoperatively he suffered generalized tonic-clonic seizures. In all patients the CsA levels were toxic and signs of neurological alterations were pre...Continue Reading

References

Sep 13, 1990·The New England Journal of Medicine·A L Mark
Mar 1, 1997·Bone Marrow Transplantation·H OpenshawE Smith
Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D J BronsterC M Miller
Dec 5, 1997·Journal of Computer Assisted Tomography·W S BartynskiD F Andrews
Aug 11, 2001·The New England Journal of Medicine·C M Filley, B K Kleinschmidt-DeMasters

❮ Previous
Next ❯

Citations

Jun 23, 2009·AJR. American Journal of Roentgenology·Alexander M McKinneyLeandro Lucato
Dec 17, 2015·Molecular Neurobiology·Sheng ChenJianmin Zhang
Jul 6, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Julie Clare McDonald, Hugh Mestitz
Oct 25, 2016·PM & R : the Journal of Injury, Function, and Rehabilitation·Katie HattEric L Altschuler
Nov 21, 2018·International Journal of Dermatology·Akanksha KaushikParamjeet Singh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Hung-Wen KaoAnton N Hasso
Survey of Ophthalmology
Daniel G Dawson, Jonathan D Trobe
Journal of Clinical Gastroenterology
Pedram J Enayati, Konstantinos A Papadakis
© 2022 Meta ULC. All rights reserved