Cyclosporine before PCI in Patients with Acute Myocardial Infarction

The New England Journal of Medicine
Thien-Tri CungMichel Ovize

Abstract

Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling. In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation myocardial infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset and who had complete occlusion of the culprit coronary artery to receive a bolus injection of cyclosporine (administered intravenously at a dose of 2.5 mg per kilogram of body weight) or matching placebo before coronary recanalization. The primary outcome was a composite of death from any cause, worsening of heart failure during the initial hospitalization, rehospitalization for heart failure, or adverse left ventricular remodeling at 1 year. Adverse left ventricular remodeling was defined as an increase of 15% or more in the left ventricular end-diastolic volume. A total of 395 patients in the cyclosporine group and 396 in the placebo group received the assigned study drug and had data that could be evaluated for the primary outcome at 1 ye...Continue Reading

References

Apr 1, 1995·The Biochemical Journal·E J Griffiths, A P Halestrap
Oct 24, 2006·The American Journal of Cardiology·Christine SavoyeUNKNOWN REmodelage VEntriculaire study group
Sep 15, 2007·The New England Journal of Medicine·Derek M Yellon, Derek J Hausenloy
Aug 2, 2008·The New England Journal of Medicine·Christophe PiotMichel Ovize
Feb 26, 2010·Cardiovascular Drugs and Therapy·Andreas SkyschallyGerd Heusch
May 8, 2010·Cardiovascular Research·Michel OvizeUNKNOWN Working Group of Cellular Biology of Heart of European Society of Cardiology
Jun 1, 2010·Heart·K A A FoxUNKNOWN GRACE and GRACE2 Investigators
Mar 27, 2012·JAMA : the Journal of the American Medical Association·Gregg W StoneUNKNOWN INFUSE-AMI Investigators
Aug 21, 2013·Basic Research in Cardiology·Damien De PaulisMichel Ovize
Dec 4, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Michael V Cohen, James M Downey
Jul 23, 2014·Anesthesiology·Pascal ChiariMichel Ovize
Apr 9, 2015·The New England Journal of Medicine·Sanjit S JollyUNKNOWN TOTAL Investigators
Apr 11, 2015·Journal of the American College of Cardiology·Borja IbáñezFrans Van de Werf

❮ Previous
Next ❯

Citations

Feb 19, 2016·Science Translational Medicine·Wang WangRong Tian
Feb 13, 2016·Journal of Interventional Cardiology·Cindy L GrinesTheodore L Schreiber
Feb 5, 2016·Nature Reviews. Cardiology·Derek J Hausenloy, Derek M Yellon
Feb 22, 2016·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·L Maximilian Buja, Richard S Vander Heide
Jan 30, 2016·Journal of the American College of Cardiology·Carol Chen-Scarabelli, Tiziano M Scarabelli
Jan 30, 2016·Journal of the American College of Cardiology·Filippo OttaniUNKNOWN CYCLE Investigators
Dec 22, 2015·Biochemical Pharmacology·Didier MorinBijan Ghaleh
Jan 5, 2016·European Heart Journal·Gilles Montalescot, Filippo Crea
Jan 14, 2016·Kidney International·Andreas Linkermann
Jan 7, 2016·The New England Journal of Medicine·Nathan MewtonMichel Ovize
Feb 24, 2016·Biochimica Et Biophysica Acta·Lucia BiasuttoMario Zoratti
Mar 26, 2016·The American Journal of Emergency Medicine·Katelin M Morrissette, Norman A Paradis
Oct 16, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Tsuyoshi Nishiguchi, Takashi Akasaka
Dec 18, 2015·Heart·Heerajnarain BulluckDerek J Hausenloy
Mar 11, 2016·Revista Española De Cardiología·Felipe Hernández HernándezRamiro Trillo Nouche
Nov 22, 2015·European Heart Journal·Thomas F Lüscher
Dec 30, 2015·Fundamental & Clinical Pharmacology·Laurent MonassierAtul Pathak
Nov 21, 2015·Cell Death and Differentiation·A LinkermannR N Kitsis
Oct 27, 2015·Cardiovascular Research·Osamu TsukamotoMasafumi Kitakaze
Sep 28, 2015·Cardiovascular Research·Gerd Heusch
Sep 1, 2015·The New England Journal of Medicine·Derek J Hausenloy, Derek M Yellon
Apr 30, 2016·International Journal of Cardiology·Judit CubedoLina Badimon
Nov 7, 2015·European Heart Journal·Fabrizio MontecuccoThomas H Schindler
May 21, 2016·Oxidative Medicine and Cellular Longevity·Danina M MunteanCristian Mornoș
May 11, 2016·Trends in Cell Biology·Valentina IzzoLorenzo Galluzzi
May 8, 2016·Resuscitation·Lars WikE Brooke Lerner
Jan 21, 2016·Fundamental & Clinical Pharmacology·Julien PottecherBernard Geny
May 18, 2016·Kidney International·Leonie G M WijermarsJan H N Lindeman
Apr 20, 2016·European Journal of Clinical Investigation·Aldo BonaventuraFranco Dallegri
May 20, 2016·Cardiovascular Research·Victoria R PellThomas Krieg
Jun 28, 2016·International Journal of Cardiology·Martin ReindlBernhard Metzler
Jul 11, 2016·International Journal of Cardiology·David C TongJamie Layland
Jul 6, 2016·International Journal of Cardiology·Xavier Rossello, Derek M Yellon
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·József Maléth, Péter Hegyi
Aug 16, 2016·Journal of the American College of Cardiology·Sunil V RaoMitchell W Krucoff
Aug 16, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zoubir DjeradaHervé Millart
Jun 17, 2016·Expert Review of Cardiovascular Therapy·Jaime A RiquelmeSergio Lavandero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Aphasia

Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.