Cyclosporine for corticosteroid-refractory acute generalized exanthematous pustulosis due to hydroxychloroquine

Dermatologic Therapy
Nicholas Bradford CastnerKiran Motaparthi

Abstract

Acute generalized exanthematous pustulosis most often manifests 1-2 days following exposure to a characteristic drug, such as aminopenicillins, calcium-channel blockers, or terbinafine. Recovery is usually rapid following drug withdrawal, and systemic corticosteroids represent the historic treatment of choice. Herein, acute generalized exanthematous pustulosis incited by hydroxychloroquine is briefly reviewed: a prolonged latency and recalcitrance to corticosteroids are noteworthy. In this unique context, cyclosporine tapered over several months is an effective therapeutic option.

References

Jul 13, 2002·Arthritis and Rheumatism·Tino MunsterDaniel E Furst
Aug 12, 2009·Clinical and Experimental Dermatology·V Di LerniaC Ricci
Sep 12, 2015·Journal of the American Academy of Dermatology·Jesse Szatkowski, Robert A Schwartz

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Citations

Mar 21, 2020·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xiang ZhangXiao-Ming Qin

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