Cyclosporine or methotrexate, which one is more promising in the treatment of lichen planopilaris?; A comparative clinical trial.

International Immunopharmacology
Farahnaz Fatemi NaeiniMina Saber

Abstract

Lichen Planopilaris (LPP) is a primary scarring alopecia with unknown etiology and its management is a challenge for dermatologists. We aimed to compare the safety and efficacy of methotrexate and cyclosporine in LPP patients. In a randomized clinical trials, 33 patients were randomly allocated to receive either 15-mg oral methotrexate per week or 3-5-mg/kg/day cyclosporine for six months. During the treatment course, side effects, signs/symptoms and laboratory test were assessed periodically. Lichen planopilaris activity index (LPPAI) was measured at baseline and 2, 4, and 6 months after the intervention. Score of both photography and patient's opinion were also obtained. The collected data were analyzed in SPSS software (Ver.25.0. Armonk, NY: IBM Corp). Both medications had positive effects on the signs and symptoms of LPP with a significant difference between the variables (p < 0.05), and the results showed similar efficacy at the end of 6th months of the therapy with both cyclosporine and methotrexate (p > 0.05). Regarding the results of the present study, both cyclosporine and methotrexate are effective in treating refractory lichen planopilaris and we propose methotrexate as a possible earlier choice over cyclosporine. Th...Continue Reading

References

Dec 1, 1992·Journal of the American Academy of Dermatology·D A MehreganS A Muller
Aug 23, 2000·Acta Dermato-venereologica·E YanaruM Ichihashi
Nov 17, 2001·Journal of the American Academy of Dermatology·S J George, S Hsu
May 21, 2003·International Journal of Dermatology·C ChieregatoP Rosina
Sep 27, 2003·Journal of the American Academy of Dermatology·Paradi MirmiraniVera H Price
May 1, 2007·Journal of the American Academy of Dermatology·Nathaniel C CevascoHaydee Ramirez de Knott
Mar 28, 2008·The British Journal of Dermatology·S GarcovichA Garcovich
Mar 18, 2009·Archives of Dermatology·Lori A SpencerJoseph C English
Apr 4, 2009·Seminars in Cutaneous Medicine and Surgery·Philippe Assouly, Pascal Reygagne
Dec 23, 2009·Archives of Dermatology·Paradi Mirmirani, Pratima Karnik
Jan 9, 2010·Histopathology·Catherine M Stefanato
Jan 12, 2010·Journal of the American Academy of Dermatology·Charles ChiangVera H Price
Jan 12, 2010·Journal of the American Academy of Dermatology·Bryan K ChoVera H Price
Feb 14, 2012·Journal of the American Academy of Dermatology·Elise A OlsenUNKNOWN Male Pattern Hair Loss Study Group
Mar 28, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·E RáczH A M Neumann
Jan 21, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M J Harries, A Messenger
Jun 11, 2014·The Journal of Dermatological Treatment·A LyakhovitskyA Barzilai
Jan 17, 2015·Journal of the American Academy of Dermatology·Natasha Atanaskova MesinkovskaWilma Bergfeld
Jun 7, 2017·International Journal of Preventive Medicine·Farahnaz Fatemi NaeiniSayed Mohsen Hosseini
Sep 26, 2017·Cutaneous and Ocular Toxicology·Emel Bulbul Baskan, Serkan Yazici
Mar 10, 2018·Clinical, Cosmetic and Investigational Dermatology·Enzo ErrichettiGiuseppe Stinco

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Citations

Aug 5, 2021·American Journal of Clinical Dermatology·Katerina SvigosJerry Shapiro

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