Cyclosporine, tacrolimus and sirolimus retain their distinct toxicity profiles despite low doses in the Symphony study

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Henrik EkbergPavel Navrátil

Abstract

Reducing side effects of immunosuppressive regimens has become a priority in transplantation medicine because of the large number of patients and grafts that succumb to infection in the short term and cardiovascular disease in the long term. The Symphony study was a 12-month prospective, randomized, open-label, multi-centre, four parallel arm study that aimed to evaluate the safety and efficacy of low-dose immunosuppressive regimens compared with a standard-dose regimen in renal transplant recipients. This sub-analysis focuses on specific toxicities observed with the low-dose regimens. Adult patients (n = 1645) scheduled to undergo renal transplantation received low-dose cyclosporine (CsA), tacrolimus (Tac) or sirolimus (SRL) in addition to daclizumab induction or standard-dose cyclosporine without induction. All patients received mycophenolate mofetil and corticosteroids. We evaluated the incidence of adverse events (AEs), tested specific group differences and assessed the relationship of selected AEs with drug levels. The four arms had similar incidences of AEs, but serious AEs were more common with low-dose SRL and led to more discontinuations. Infections were the most common AEs, with the highest incidence in the standard-d...Continue Reading

References

Feb 1, 1988·Kidney International·B D MyersN S Coplon
Feb 15, 1997·Transplantation·J A Kobashigawa, B L Kasiske
Jul 23, 1999·Renal Failure·W F Finn
Jan 5, 2000·Kidney International·A O OjoF K Port
Feb 17, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A M de MattosW M Bennett
May 15, 2002·Dementia and Geriatric Cognitive Disorders·Anna F PetterssonLars-Olof Wahlund
Sep 10, 2002·Current Hypertension Reports·John J Curtis
Oct 28, 2003·Diabetes Care·Saul GenuthUNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jul 23, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Josep María GrinyoEnrique Granados
May 27, 2005·Journal of the American Society of Nephrology : JASN·Daniel AbramowiczUNKNOWN Cyclosporine Withdrawal Study Group
May 28, 2005·Transplantation Proceedings·Z WlodarczykUNKNOWN TERRA Study Group
Oct 26, 2005·The Annals of Thoracic Surgery·David S Bach
Nov 10, 2005·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Donna Young
Jul 14, 2006·Journal of the American Society of Nephrology : JASN·Jamal BamoulidDidier Ducloux
Jan 19, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H EkbergM Rashford
Mar 6, 2007·Drugs·Joshua J AugustineDonald E Hricik
Mar 16, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F VincentiN Goto
Dec 21, 2007·The New England Journal of Medicine·Henrik EkbergUNKNOWN ELITE-Symphony Study
May 28, 2009·Journal of the American Society of Nephrology : JASN·Dario CattaneoUNKNOWN Mycophenolate Steroids Sparing (MYSS) Genetics Study Group

❮ Previous
Next ❯

Citations

Jul 26, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fritz DiekmannJosep M Campistol
Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Jun 26, 2013·American Journal of Nephrology·Naim IssaHassan N Ibrahim
Mar 12, 2013·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Antoine Barbari
Oct 24, 2013·Clinical & Developmental Immunology·Gianluigi ZazaAntonio Lupo
May 9, 2014·Journal of Nephrology·Gianluigi ZazaAntonio Lupo
May 9, 2012·Expert Opinion on Biological Therapy·Swati AroraKalathil K Sureshkumar
Dec 17, 2015·Expert Opinion on Drug Safety·Pedro Ventura AguiarFritz Diekmann
Aug 28, 2010·Kidney International. Supplement·David Goldsmith, Carolynn E Pietrangeli
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C N Kotton
Mar 23, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Andreas Zuckermann, Markus J Barten
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M PoglitschM D Säemann
Mar 19, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Marc LúciaOriol Bestard
Apr 1, 2016·British Journal of Haematology·Jintao WangDaniel T Eitzman
Oct 7, 2014·Pediatric Transplantation·Nicholas Larkins, Douglas G Matsell
Mar 27, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Renaud SnanoudjChristophe Legendre
Jan 23, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Stephan SchlickeiserBirgit Sawitzki
Oct 6, 2011·Immunopharmacology and Immunotoxicology·HyeonSeok HwangChul Woo Yang
Dec 12, 2012·Expert Opinion on Pharmacotherapy·Thomas Rath
Jul 26, 2014·Medicina·Aurelija NoreikaitėEdgaras Stankevičius
Sep 18, 2014·Transplantation Reviews·Hallvard HoldaasFaouzi Saliba
Aug 3, 2013·Thrombosis Research·Marije C BaasFrederike J Bemelman
May 18, 2016·International Journal of Molecular Sciences·Simona GranataGianluigi Zaza
Nov 29, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B HöckerB Tönshoff
Jun 10, 2016·European Journal of Drug Metabolism and Pharmacokinetics·Kannan Sridharan, Gowri Sivaramakrishnan
Sep 1, 2016·Health Technology Assessment : HTA·Tracey Jones-HughesRob Anderson
Oct 21, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Julio PascualUNKNOWN Spanish Society of Transplantation Virological and Immune Response Investigation Study Group
Oct 28, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Carlos CerveraFrederic Oppenheimer
Mar 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N GaudreA Del Bello
May 18, 2017·Clinical Pharmacology and Therapeutics·H A ChakkeraB Kaplan
Jul 21, 2011·Nature Reviews. Neuroscience·Jordi BovéMiquel Vila
Jul 30, 2014·Transplantation·Florence AulagnonJulien Zuber
Jun 4, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ana Elena Rodriguez-RodriguezEsteban Porrini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
H Tedesco SilvaY S Kim
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Vivek N AhyaSangeeta Bhorade
© 2021 Meta ULC. All rights reserved