PMID: 25741648Mar 6, 2015Paper

Cyclosporine versus tacrolimus: cost-effectiveness analysis for renal transplantation in Brazil

Revista de saúde pública
Augusto Guerra JúniorFrancisco de Assis Acúrcio

Abstract

OBJECTIVE To analyze the cost-effectiveness of treatment regimens with cyclosporine or tacrolimus, five years after renal transplantation. METHODS This cost-effectiveness analysis was based on historical cohort data obtained between 2000 and 2004 and involved 2,022 patients treated with cyclosporine or tacrolimus, matched 1:1 for gender, age, and type and year of transplantation. Graft survival and the direct costs of medical care obtained from the National Health System (SUS) databases were used as outcome results. RESULTS Most of the patients were women, with a mean age of 36.6 years. The most frequent diagnosis of chronic renal failure was glomerulonephritis/nephritis (27.7%). In five years, the tacrolimus group had an average life expectancy gain of 3.96 years at an annual cost of R$78,360.57 compared with the cyclosporine group with a gain of 4.05 years and an annual cost of R$61,350.44. CONCLUSIONS After matching, the study indicated better survival of patients treated with regimens using tacrolimus. Moreover, regimens containing cyclosporine were more cost-effective [corrected].

References

Mar 13, 2002·Lancet·Raimund Margreiter, UNKNOWN European Tacrolimus vs Ciclosporin Microemulsion Renal Transplantation Study Group
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·Bruce KaplanHerwig-Ulf Meier-Kriesche
Jun 12, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Miguel Angel GentilManuel López De Mendoza Martínez
Mar 3, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bernhard K KrämerUNKNOWN European Tacrolimus vs Cyclosporin Microemulsion Renal Transplantation Study Group
Dec 21, 2007·The New England Journal of Medicine·Alan B Leichtman
Dec 17, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Olivier PrinceMichael J Mihatsch
Mar 20, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Jan Steffen JürgensenBastian Hass
Mar 21, 2009·Transplantation·Gerhard OpelzUNKNOWN Collaborative Transplant Study
Feb 2, 2010·Seminars in Nephrology·Elisa J GordonJohn Franklin
Mar 9, 2010·Cadernos de saúde pública·Augusto Afonso Guerra JuniorGrazielle Dias da Silva
Aug 3, 2010·Revista de saúde pública·Mariangela Leal CherchigliaIsabel Cristina Gomes

❮ Previous
Next ❯

Citations

May 18, 2016·Expert Review of Clinical Pharmacology·Rosângela Maria GomesFrancisco Assis Acurcio
Nov 17, 2016·Revista de saúde pública·Aylene Bousquat, Oswaldo Yoshimi Tanaka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.