Cyclosporine versus tacrolimus in patients with HCV infection after liver transplantation: effects on virus replication and recurrent hepatitis

World Journal of Gastroenterology : WJG
P HilgardG Gerken

Abstract

To determine the effects of the calcineurin inhibitors, cyclosporine and tacrolimus, on hepatitis C virus (HCV) replication and activity of recurrent hepatitis C in patients post liver transplantation. The data of a cohort of 107 patients who received liver transplantation for HCV-associated liver cirrhosis between 1999 and 2003 in our center were retrospectively analyzed. The level of serum HCV-RNA and the activity of recurrent hepatitis were compared between 47 patients who received either cyclosporine or tacrolimus as the primary immunosuppressive agent and an otherwise similar immunosuppressive regimen which did not lead to biliary complications within the first 12 mo after transplantation. HCV-RNA increased within 3 mo after transplantation but the differences between the cyclosporine group and the tacrolimus group were insignificant (P=0.49 at 12 mo). In addition, recurrent hepatitis as determined by serum transaminases and histological grading of portal inflammation and fibrosis showed no significant difference after 12 mo (P=0.34). Cyclosporine or tacrolimus as a primary immunosuppressive agent does not influence the induction or severity of recurrent hepatitis in HCV-infected patients after liver transplantation.

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Citations

Jun 3, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhe LiuHengli Tang
Oct 3, 2009·Digestive Diseases and Sciences·Roberto J FirpiDavid R Nelson
Dec 17, 2009·Expert Opinion on Investigational Drugs·Robert Flisiak, Anna Parfieniuk
Jul 16, 2013·Viruses·Stephen D FraustoHengli Tang
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Aug 24, 2007·Expert Opinion on Investigational Drugs·Robert FlisiakRaf Crabbé
Nov 8, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Alexandra FreyKerstin Herzer
Aug 1, 2010·Viruses·Hengli Tang
Oct 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James R Burton, Hugo R Rosen

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