Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice

The Journal of Pain : Official Journal of the American Pain Society
Luis ConstandilTeresa Pelissier

Abstract

Several lines of evidence indicate that brain-derived neurotrophic factor (BDNF) plays a key role as a central pronociceptive modulator of pain, acting through postsynaptic TrkB receptors that trigger intracellular signaling cascades leading to central sensitization. The overall aim of this study was to investigate to what extent BDNF could participate in the generation and maintenance of trigeminal neuropathic pain. The results showed that acute intracisternal administration of nanogram doses of BDNF in naïve mice elicited long-lasting, dose-related, cold allodynic responses to topical application of acetone onto vibrissal pad skin. The systemic administration of cyclotraxin-B (CTX-B), a new TrkB receptor antagonist, or propentofylline, an inhibitor of glial activation, was able to either prevent or reverse the effects of intracisternal BDNF on cold nociception. In addition, the blockade of TrkB receptor by CTX-B inhibited the mechanisms that either initiate or maintain cold allodynia in the ipsilateral vibrissal pad skin after unilateral constriction of the infraorbital nerve. These observations raise the possibility that BDNF is capable on its own of conveying many features of the signaling mechanisms that underlie central s...Continue Reading

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Citations

Aug 28, 2012·Arthritis Research & Therapy·Francisco MoralesClaudio Laurido
Jun 21, 2014·Biologie aujourd'hui·Sophie Pezet
Apr 23, 2014·Molecular Neurobiology·Mette RichnerChristian Bjerggaard Vaegter
Jul 28, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·D BravoL Constandil
Mar 18, 2016·Brain : a Journal of Neurology·Gabriela TrevisanRomina Nassini
Sep 8, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Saïd M'DahomaSylvie Bourgoin
Jul 3, 2021·International Journal of Molecular Sciences·Yukinori NagakuraTakahiro Kurose

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