Cyclotron production of high purity (44m,44)Sc with deuterons from (44)CaCO3 targets

Nuclear Medicine and Biology
C AlliotS Huclier-Markai

Abstract

Due to its longer half-life, (44)Sc (T1/2 = 3.97 h) as a positron emitter can be an interesting alternative to (68)Ga (T1/2 = 67.71 min). It has been already proposed as a PET radionuclide for scouting bone disease and is already available as a (44)Ti/(44)Sc generator. (44)Sc has an isomeric state, (44 m)Sc (T1/2 = 58.6 h), which can be co-produced with (44)Sc and that has been proved to be considered as an in-vivo PET generator (44 m)Sc/(44)Sc. This work presents the production route of (44 m)Sc/(44)Sc generator from (44)Ca(d,2n), its extraction/purification process and the evaluation of its performances. Irradiation was performed in a low activity target station using a deuteron beam of 16 MeV, which favors the number of (44 m)Sc atoms produced simultaneously to (44)Sc. Typical irradiation conditions were 60 min at 0.2 μA producing 44 MBq of (44)Sc with a (44)Sc/(44 m)Sc activity ratio of 50 at end of irradiation. Separations of the radionuclides were performed by means of cation exchange chromatography using a DGA® resin (Triskem). Then, the developed process was applied with bigger targets, and could be used for preclinical studies. The extraction/purification process leads to a radionucleidic purity higher than 99.99% ((43...Continue Reading

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Citations

Sep 20, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Katarzyna SzkliniarzWiktor Zipper
Feb 13, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Thomas W PriceGraeme J Stasiuk
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Jun 20, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Gábor NagyGyörgy Trencsényi
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Apr 10, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Lily LiChris Orvig
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Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai

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