Cyfra 21-1 as a biologic marker of non-small cell lung cancer. Evaluation of sensitivity, specificity, and prognostic role

Chest
B WieskopfE Quoix

Abstract

Cytokeratins are epithelial markers whose expression is not lost during malignant transformation. Cyfra 21-1 is a cytokeratin-19 fragment that is soluble in serum and may be a useful circulating tumor marker. The aims of this study were (1) to confirm sensitivity and specificity of Cyfra 21-1 in detecting non-small cell lung cancer (NSCLC) and especially the squamous cell subtype, (2) to assess the potential relationship between Cyfra 21-1 and disease stage of the disease in NSCLC, and (3) to evaluate prognostic effect of Cyfra 21-1 in NSCLC. An immunoradiometric assay of serum Cyfra 21-1 was performed in 161 patients with lung cancers and 71 others with benign lung diseases. The ability of Cyfra 21-1 to detect different histologic subtypes of lung cancer vs benign lung diseases was assessed through receiver operating characteristic (ROC) curves and comparisons with other tumor markers such as carcinoembryonic antigen, neuron-specific enolase, and squamous cell carcinoma antigen. Comparisons of Cyfra 21-1 levels according to histologic subtype and disease stage were done using Kruskal-Wallis test. Independent prognostic value of Cyfra 21-1 was studied with a multivariate analysis of survival (Cox's model). Using a threshold of ...Continue Reading

References

Feb 11, 1991·International Journal of Radiation Oncology, Biology, Physics·P BonomiW Warren
Jan 1, 1990·International Journal of Epidemiology·D T Carr
Feb 1, 1987·European Journal of Cancer & Clinical Oncology·M KasperU Karsten
Aug 1, 1987·European Journal of Cancer & Clinical Oncology·J P SculierJ Fruhling
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D RastelB Thirion
Aug 1, 1993·Cancer·P StieberA Fateh-Moghadam

❮ Previous
Next ❯

Citations

Apr 25, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Thomas PoeschingerWerner Scheuer
Sep 29, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G BuccheriUNKNOWN Cuneo Lung Cancer Study Group
Feb 13, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·J L PujolX Quantin
Aug 2, 2003·Cancer Detection and Prevention·Li ZhongEdward A Hirschowitz
Sep 29, 2011·Molecular & Cellular Proteomics : MCP·Mariana Guergova-KurasLászló Takács
Oct 10, 1998·Respirology : Official Journal of the Asian Pacific Society of Respirology·H NakahamaM Sugita
Jan 22, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Giuseppe Lo RussoPatrizia Seminara
Jul 23, 2013·International Journal of Medical Sciences·Laura BoyeroMa Esther Fárez-Vidal
Apr 18, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kosuke TanakaNobuyuki Katakami
Aug 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yoo Jin HongKyu Ok Choe
Mar 22, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hiroaki SatohKiyohisa Sekizawa
Nov 26, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Zhuang YuShi-Hai Liu
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Hee Keun GwakSeok Gun Park
Oct 12, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rui Huan XuWen Bin Yuan
May 9, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·H HamakawaH Tanioka
Feb 24, 2017·Surgery Today·Haruhiko Nakamura, Toshihide Nishimura
May 29, 2018·Digestive Diseases·Sven H LoosenTom Luedde
Oct 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Arthur ChoByoung Wook Choi
Feb 22, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hiromichi ShirasuToshiaki Takahashi
Feb 5, 2000·Seminars in Surgical Oncology·C L Lau, D H Harpole
Oct 2, 2019·Current Molecular Medicine·Roghayeh SheervalilouNosratollah Zarghami
Jun 14, 2017·BioMed Research International·Linjie LiuMingjun Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The European Respiratory Journal
M RapellinoE Chyczewska
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
D RastelB Thirion
© 2021 Meta ULC. All rights reserved