CYFRA 21-1 predicts the efficacy of nivolumab in patients with advanced lung adenocarcinoma

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Hiromichi ShirasuToshiaki Takahashi

Abstract

CYFRA 21-1 is a prognostic marker for non-small cell lung cancer. The serum CYFRA 21-1 level is also known as an adjunct for the diagnosis of lung squamous cell carcinoma. This study aimed to examine whether CYFRA 21-1 has predictive implications for nivolumab therapy in patients with advanced lung adenocarcinoma. Of the 79 patients who were treated with nivolumab therapy at the Shizuoka Cancer Center between December 2015 and September 2016, we retrospectively reviewed the data of 50 patients. The patient characteristics were as follows: age <70/≥70 years: 43 (86%)/7; male/female: 31 (62.0%)/19; Eastern Cooperative Oncology Group performance status 0-1/2: 43 (86%)/7; smoking status: no/yes: 18 (36%)/32; epidermal growth factor receptor mutation status negative/positive: 36 (72%)/14; CYFRA 21-1 ≥2.2/<2.2 ng/mL: 28 (56%)/22; carcinoembryonic antigen ≥5/<5 ng/mL: 29 (58%)/21; and number of prior regimens 2-3/≥4: 16 (32%)/34. With a median follow-up of 263.5 (range, 64-352) days, the median progression-free survival was 70 days. The clinical variables investigated using univariate analysis were as follows: age (p = 0.423), carcinoembryonic antigen (p = 0.888), epidermal growth factor receptor mutation status (p = 0.105), performan...Continue Reading

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Citations

Jan 8, 2020·The Open Respiratory Medicine Journal·Nobuhiro KanajiTomoya Ishii
Jul 6, 2021·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mirte MullerMichel M van den Heuvel

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Methods Mentioned

BETA
biopsies
exome sequencing

Software Mentioned

EZR

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