Cylindromatosis--A Protective Molecule against Liver Diseases

Medicinal Research Reviews
Claus Hellerbrand, Ramin Massoumi

Abstract

Cylindromatosis (CYLD) is a deubiquitination enzyme involved in the regulation of different cellular processes including inflammation, fibrosis, and cancer. The function of CYLD is via deubiquitination of specific substrates in different signaling pathways including NF-κB, Notch, and JNK. CYLD contributes to hepatic homeostasis and restoration upon liver injury. Mutation or disruption of the activity of CYLD in animals aggravates acute as well as chronic liver injury and promotes development and progression of hepatocellular cancer. This is mediated by a shift of the balance toward pro-inflammatory, pro-fibrogenic, and pro-oncogenic pathways. In this review, we will explain the liver-associated signaling pathways that CYLD regulates in hepatocytes and nonparenchymal liver cells under physiological and pathological conditions. We will also describe the most recent findings concerning CYLD-mediated downstream signaling in the liver in situations such as injury, infection, inflammation, and cancer. Furthermore, we will discuss the potential of novel diagnostic tools and treatment strategies utilizing CYLD and its target genes.

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Citations

Apr 25, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Biao Hu, Sem H Phan
May 14, 2016·Journal of Cell Science·Yunfan Yang, Jun Zhou
Jan 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kensei KomatsuJian-Dong Li
May 1, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Zhiyong DuCuifeng Wei

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