Cynomolgus monkey model for experimental Q fever infection

The Journal of Infectious Diseases
J C GonderE W Larson

Abstract

A subhuman primate model was developed for study of the pathogenesis of infection with Coxiella burnetii. Cynomolgus monkeys (Macaca fascicularis) that were exposed to 10(5) mouse median infectious intraperitoneal doses of C. burnetii in a small-particle aerosol developed clinical signs of illness and pathologic changes characteristic of Q fever infection in humans. All monkeys had radiologic evidence of pneumonia by day 9. Antibodies to C. burnetii were detectable by the indirect fluorescent antibody test by day 7. These data indicate that the cynomolgus monkey is a suitable model for study of the pathogenesis of Q fever infection and may prove valuable in the evaluation of C. burnetii vaccines.

Citations

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Related Concepts

Aerosol Dose Form
Metazoa
Anthropoidea
Antibodies, Bacterial
Coxiella
Immunofluorescence Assay
Macaca
Macaca fascicularis
Experimental Lung Inflammation
Chronic Q Fever

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