PMID: 8961239Dec 1, 1996Paper

CYP 2D6 PM phenotype hypothesis of antidepressant extrapyramidal side-effects

Medical Hypotheses
P VandelP Bizouard

Abstract

Extrapyramidal symptoms occur as side-effects of neuroleptics. For many years, case reports of such side-effects, linked to antidepressant treatments, have been published, but this phenomenon is not well known. Tricyclic and serotonergic antidepressants are both involved. The authors present an hypothesis which provides one possible neurobiochemical explanation for the aetiology of these side-effects. The proposed explanation is related to the inhibition of the CYP 2D6 isoenzyme by antidepressants (or neuroleptics) that may be involved in the genesis of the observed extrapyramidal side-effects.

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Citations

Aug 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·P VandelP Bizouard
Jan 8, 2004·Journal of Clinical Psychopharmacology·Stephen V FaraoneJoseph Biederman

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