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CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver

Human & Experimental Toxicology

May 1, 1996

S PennanenH Komulainen

PMID: 8735469

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Abstract

1. The metabolism of 2-ethylhexanoic acid (2-EHA) was studied in rat, mouse and human liver microsomes in vitro. The metabolites of 2-EHA were identified as methylated derivatives by gas chromatography-mass spectrometry. 2. 2-Ethyl-1,6-hexanedioic acid was the main metabolite produced i...read more

Mentioned in this Paper

Metabolic Process, Cellular
Monoclonal Antibodies
Quinidex
Human urine
Derivatives
NADPH-Ferrihemoprotein Reductase
CYP2A7 gene
SU 4885
CYP2D6 wt Allele
Microsomes
Paper Details
References
  • References27
  • Citations3
123

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Mechanisms of CYP450

Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.

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Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process

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Hao SunGarold S Yost
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CYP enzymes catalyze the formation of a terminal olefin from 2-ethylhexanoic acid in rat and human liver

Human & Experimental Toxicology

May 1, 1996

S PennanenH Komulainen

PMID: 8735469

DOI:

Abstract

1. The metabolism of 2-ethylhexanoic acid (2-EHA) was studied in rat, mouse and human liver microsomes in vitro. The metabolites of 2-EHA were identified as methylated derivatives by gas chromatography-mass spectrometry. 2. 2-Ethyl-1,6-hexanedioic acid was the main metabolite produced i...read more

Mentioned in this Paper

Metabolic Process, Cellular
Monoclonal Antibodies
Quinidex
Human urine
Derivatives
NADPH-Ferrihemoprotein Reductase
CYP2A7 gene
SU 4885
CYP2D6 wt Allele
Microsomes

Feeds With Similar Papers

Mechanisms of CYP450

Cytochrome P450 (CYP450) are a family of enzymes involved in two major processes, such as the synthesis of fatty acids, steroids, and biles acids, and the metabolism of toxins and drugs. Discover the latest research on the Mechanisms of CYP450 enzymes here.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics

Dehydrogenation of indoline by cytochrome P450 enzymes: a novel "aromatase" process

The Journal of Pharmacology and Experimental TherapeuticsMay 16, 2007
Hao SunGarold S Yost
Paper Details
References
  • References27
  • Citations3
123

Download from

PubMed
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