CYP17, CYP1A1 and COMT polymorphisms and the risk of adenomyosis and endometriosis in Taiwanese women

Human Reproduction
S H JuoE M Tsai

Abstract

The aim of the study was to test whether the COMT, CYP1A1 and CYP17 genes influence the risk of developing adenomyosis and endometriosis. We conducted two case-control studies, where the cases (n = 198) had either of the two diseases, and controls (n = 312) were disease-free women. For the COMT gene, we selected the G/A nonsynonymous single-nucleotide polymorphism (SNP) that leads to valine-to-methionine (Val/Met) substitution. For the CYP1A1 gene, we used a functional T/C SNP in the 3'-noncoding region, and we genotyped a T/C functional SNP in the 5' region of the CYP17 gene for the present study. Hardy-Weinberg equilibrium was checked in both cases and controls. Logistic regression models were used to evaluate the genetic effect, with adjustment for other covariates. We found that the homozygous COMT genotype that encodes low enzyme activity had an increased risk for adenomyosis with an age-adjusted odds ratio of 3.2 (95% confidence interval 1.3-7.8; P = 0.006). The COMT gene, however, was not associated with endometriosis. Neither the CYP1A1 nor CYP17 genes had any significant association with either of the two diseases. The COMT gene significantly influences the risk of adenomyosis but not endometriosis. The present study d...Continue Reading

References

Jan 1, 1986·Journal of Steroid Biochemistry·J G LiehrA Ari-Ulubelen
Sep 1, 1993·American Journal of Obstetrics and Gynecology·T YamamotoH Okada
Dec 9, 1997·Fertility and Sterility·R M HadfieldS H Kennedy
May 25, 1999·Cancer Detection and Prevention·E TaioliS J Garte
Apr 13, 2002·Annals of the New York Academy of Sciences·Joe Leigh Simpson, Farideh Z Bischoff
Aug 10, 2002·Journal of Assisted Reproduction and Genetics·Fritz WieserChristian Schneeberger
Mar 7, 2003·Fertility and Sterility·Demetrios A ArvanitisDemetrios A Spandidos
Apr 13, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tasneem AsgharTakeshi Maruo
May 5, 2005·American Journal of Epidemiology·L F MassonJ Little
Nov 15, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hsiu-Ting TsaiMing-Tsang Wu

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Citations

Feb 1, 2013·Journal of Human Genetics·Eing-Mei TsaiSuh-Hang H Juo
Sep 23, 2008·Human Reproduction Update·C B TempferB C J M Fauser
Aug 21, 2007·Obstetrical & Gynecological Survey·Henrik FalconerGabriel Fried
Jul 18, 2014·Environmental Science and Pollution Research International·Po-Chin HuangShu-Li Wang
May 23, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xueying HuBo Wei
Feb 2, 2010·Reproductive Biomedicine Online·Gurkan BozdagTimur Gurgan
Oct 22, 2008·Fertility and Sterility·Maria Teresa VietriLuigi Cobellis
Oct 22, 2008·Fertility and Sterility·Suh-Hang Hank JuoEing-Mei Tsai
Aug 30, 2008·Maturitas·Emerson de OliveiraManoel João Batista Castello Girão
Jul 3, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Malgorzata SzczepańskaPaweł P Jagodziński
Dec 17, 2014·The Journal of Obstetrics and Gynaecology Research·Hong-Yan ChenLing Shi
Jun 27, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Xiang TongHong Fan
Apr 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Denise Maria ChristofoliniCaio Parente Barbosa
Aug 16, 2016·Journal of Assisted Reproduction and Genetics·Wei FanQianhong Ma
Mar 27, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Danilo DeianaStefano Angioni
Dec 15, 2012·Molecular and Cellular Biochemistry·Omer AtesSaime Sezer
Dec 11, 2019·Human Reproduction Update·Loren MéarFrançois Vialard
Apr 17, 2019·Experimental and Therapeutic Medicine·Loukia VassilopoulouGeorge N Goulielmos

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