CYP17 genetic polymorphism in endometrial cancer: are only steroids involved?

Cancer Letters
L M BersteinIrina G Kovalenko

Abstract

Initiation and/or promotion of endometrial cancer is known to be associated with estrogen and androgen (androstenedione) excess as well as with hyperinsulinemia/insulin resistance. It is possible that some allelic polymorphisms of the genes involved in steroidogenesis or steroid metabolism contribute to endometrial cancer susceptibility. We evaluated here the role of CYP17 biallelic (MspAI) polymorphism in 114 endometrial cancer patients compared with 182 healthy women. Our data demonstrated that A2/A2 CYP17 genotype, considered on the basis of initial breast cancer studies as 'unfavorable', was under-represented in endometrial cancer group (odds ratio 0.48, 95% confidence interval 0.25-0.89) that confirmed results of two other recent investigations. Carriers of this genotype were characterized by having lower blood insulin (by 120 min of oral glucose tolerance test 36.7+/-3.9 microU/ml vs. 90.4+/-16.7 microU/ml in postmenopausal women with A1/A1 genotype, P=0.04) and C-peptide levels (after night fasting 575.2+/-78.3 pg/ml vs. 978.9+/-115.7 pg/ml, respectively, P=0.04). No significant difference was found between the mean concentrations of testosterone, dehydroepiandrosterone sulfate and estradiol concentrations in patients-ca...Continue Reading

References

Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Dec 1, 1995·Mutation Research·H O AdamiD Trichopoulos
Aug 21, 1996·Journal of the National Cancer Institute·N PotischmanJ R Lurain
Mar 1, 1997·British Journal of Hospital Medicine·D Semple
Oct 3, 1999·Current Opinion in Oncology·R E Bristow
Dec 11, 1999·Pharmacogenetics·M WadeliusE Rane
Feb 26, 2000·Carcinogenesis·B E Henderson, H S Feigelson
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M E Sherman
Apr 18, 2000·Mutation Research·V N Kristensen, A L Borresen-Dale
Aug 10, 2000·The Journal of Clinical Investigation·M P Stern
Nov 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y MiyoshiS Noguchi
Feb 15, 2001·Endocrine-related Cancer·G EmonsW Heyl
Feb 24, 2001·Journal of Cancer Research and Clinical Oncology·L M BersteinV B Gamajunova
Jul 31, 2001·Human Reproduction Update·S FranksM McCarthy
Oct 12, 2001·Hormone Research·M PugeatM Mallion-Donadieu
Nov 3, 2001·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·K Pavelić, K Gall-Troselj

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Citations

Jan 4, 2008·Human Genetics·Mia M GaudetMontserrat Garcia-Closas
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M AbanA Altintas
Mar 25, 2006·Future Oncology·Sokbom KangJae Weon Kim
Nov 8, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Anne KendallMitch Dowsett
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·M Patricia MadiganAnn W Hsing
Mar 3, 2009·Annals of the New York Academy of Sciences·Luisa M Massimo, Gian Paolo Tonini
Oct 20, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Elizabeth J FolkerdMitch Dowsett
Apr 24, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xueying YangYujun An
Nov 18, 2006·American Journal of Epidemiology·Sara H OlsonIrene Orlow
May 10, 2005·Human Reproduction·Chanley M SmallHeather Spencer Feigelson
Dec 29, 2005·International Journal of Cancer. Journal International Du Cancer·Lifang HouAnn W Hsing
Jul 1, 2008·Expert Review of Anticancer Therapy·Larissa A MeyerMichael R Milam
Feb 12, 2004·Cancer Research·Yannick DuguayImmaculata De Vivo

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