CYP17 genetic polymorphism in patients with endometrial hyperplasia and cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
M AbanA Altintas

Abstract

We investigated the association of CYP17 gene polymorphism with the risk of having endometrial cancer and a well-known precursor of it, endometrial hyperplasia. Group A (control group) consisted of 35 patients who had histologically proven normal endometrium. Group B and C consisted of 18 and 30 patients who had endometrial hyperplasia with and without atypia, respectively. Group D consisted of 57 patients who had endometrial cancer. Venous blood samples were collected from patients in groups, and polymerase chain reaction was performed to determine the CYP17 gene polymorphism. Significant increase of A1/A1 and a decrease of A1/A2 genotype frequencies have been determined in patients with endometrial cancer and with atypical endometrial hyperplasia. No significant differences were found between groups in the frequency of A2/A2 genotype. There was no significant difference between the groups in the meaning of allele distributions. CYP17 polymorphism had correlation with endometrial atypia and cancer. Related effects of different types of CYP17 gene variants on the progression of hyperplastic endometrial cells into carcinoma should be evaluated in further studies. Progress in this area would help us modulate preventive treatments...Continue Reading

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Citations

Jan 4, 2008·Human Genetics·Mia M GaudetMontserrat Garcia-Closas
May 6, 2011·International Journal of Cancer. Journal International Du Cancer·Pedram RazaviGiske Ursin
Mar 6, 2015·Oxidative Medicine and Cellular Longevity·Tatiana I IvanovaLyubov E Salnikova
Nov 18, 2006·American Journal of Epidemiology·Sara H OlsonIrene Orlow
Apr 24, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xueying YangYujun An

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