CYP1A1 and GSTM1 polymorphic genotypes in patients with prostate cancer in a Turkish population

Cancer Genetics and Cytogenetics
Dilek AktasErgul Tuncbilek

Abstract

Despite high incidence rates of prostate cancer, the genetic basis of this disease is not well understood. An association between risk and the CYP1A1 polymorphism has been noticed for several cancers, and the GSTM1 gene is one of the most extensively studied genes concerning polymorphism and cancer risk. These gene polymorphisms may play a role in the development prostate cancer (PCa) in Turkish populations; we therefore assessed the association of CYP1A1 and GSTM1 polymorphisms in patients with PCa in our population through a case-control study. One hundred patients with PCa and 107 control subjects were analyzed with an allele-specific polymerase chain reaction method. No statistical differences in the distribution of the CYP1A1 Ile/Val genotype among PCa individuals were observed (OR = 1.076, 95% CI = 0.605-1.913). The patients with CYP1A1 Val/Val revealed a 2.8-fold higher risk of having prostate cancer than those with the wild-type Ile/Ile (OR = 2.846, 95% CI = 1.004-8.064). In other words, the presence of the Val/Val genotype significantly increased the risk of prostate cancer. The GSTM1 null genotype was found in 13.1% of the control subjects; no statistical differences were noted in the frequency of the null genotype in...Continue Reading

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Citations

Nov 23, 2010·Pathology Oncology Research : POR·Zahra Ousati AshtianiMohammad Hossein Modarressi
Feb 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guangye HanFeng Zhu
Jun 29, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I EsinlerA Ayhan
Mar 25, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Alfredo SantovitoMassimiliano Delpero
Oct 25, 2011·Cancer Epidemiology·Randa G NaffaSaid I Ismail
Oct 23, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Sinem AkgülDilek Aktaş
Nov 29, 2015·Technology in Cancer Research & Treatment·Zhong-Yang WangGregor P C Drummen
Feb 7, 2012·Genetic Testing and Molecular Biomarkers·Yousra SouidenKacem Mahdouani
Apr 17, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Gulzar BhatBashir Ganai
Oct 16, 2012·Molecular Biology Reports·Huawen LiTaiping He

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