CYP1B1 and hormone-induced cancer

Cancer Letters
Ketan GajjarFrancis L Martin

Abstract

Cancers in hormone-responsive tissues (e.g., breast, ovary, endometrium, prostate) occur at high incidence rates worldwide. However, their genetic basis remains poorly understood. Studies to date suggest that endogenous/exogenous oestrogen and environmental carcinogens may play a role in development and/or progression of hormone-induced cancers via oxidative oestrogen metabolism. Cytochrome P450 1B1 is a key enzyme in its oestrogen metabolism pathway, giving rise to hydroxylation and conjugation. Although CYP1B1 is expressed in many cancers, particularly high levels of expression are observed in oestrogen-mediated disease. CYP1B1 is more readily found in tumour tissue compared to normal. Given the role of CYP1B1 in pro-carcinogen and oestrogen metabolism, polymorphisms in CYP1B1 could result in modifications in its enzyme activity and subsequently lead to hormone-mediated carcinogenesis. CYP1B1 may also be involved in progression of the disease by altering the tissue response to hormones and clinical response to chemotherapy. The exact mechanism behind these events is complex and unclear. Only a few functional single nucleotide polymorphisms of CYP1B1 are known to result in amino acid substitutions and have been extensively inv...Continue Reading

References

May 1, 1990·Mutation Research·J G Liehr
Jul 17, 1971·Lancet·M F Fathalla
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G Liehr, M J Ricci
Jan 1, 1996·Critical Reviews in Eukaryotic Gene Expression·F Cavalieri
Nov 8, 1996·The Journal of Biological Chemistry·Y M TangW F Greenlee
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·E L CavalieriE G Rogan
Jun 1, 1997·The Journal of Steroid Biochemistry and Molecular Biology·D C SpinkT R Sutter
Feb 17, 1998·Cancer Letters·S V VadlamuriM A Sarkar
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·H HellmoldJ A Gustafsson
Feb 26, 2000·Carcinogenesis·B E Henderson, H S Feigelson
Mar 4, 2000·Endocrine Reviews·J G Liehr
Jun 28, 2000·Archives of Biochemistry and Biophysics·R A McLellanM Ingelman-Sundberg
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·B L BrockdorffA E Lykkesfeldt
Jan 13, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L MuskhelishviliF F Kadlubar
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·L ZhengT G Boyer
Dec 12, 2001·Journal of Theoretical Biology·A A PatelR A Gatenby
Jan 5, 2002·Breast Cancer Research and Treatment·M IscanH Raunio
Feb 21, 2002·Molecular Pharmacology·Eleni AklilluMagnus Ingelman-Sundberg
Aug 30, 2002·Biochemical and Biophysical Research Communications·Yuichiro TanakaRajvir Dahiya
Oct 19, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Bruno Bournique, Audrey Lemarié
Jul 8, 2003·Carcinogenesis·Tove Rylander-RudqvistIngemar Persson
Sep 13, 2003·Carcinogenesis·David C SpinkBarbara C Spink
Jun 1, 1958·Archives of Biochemistry and Biophysics·M KLINGENBERG
Dec 4, 2003·Chemico-biological Interactions·Minoti SharmaJames R Olson

❮ Previous
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Citations

Nov 6, 2013·Disease Markers·S VimalrajN Selvamurugan
Jun 21, 2013·International Journal of Circumpolar Health·Mandana GhisariEva C Bonefeld-Jørgensen
Nov 26, 2013·International Journal of Molecular Medicine·Marjaneh MotaghedShahrul Sahul Hamid
Jul 11, 2013·Pharmacogenomics·Daniel L Hertz
Nov 8, 2014·Proceedings. Biological Sciences·Takafumi KatsumuraHiroki Oota
Aug 15, 2013·Expert Opinion on Drug Metabolism & Toxicology·Tewes Tralau, Andreas Luch
Jan 22, 2013·Drug Metabolism Reviews·Sabine Gerbal-ChaloinMartine Daujat-Chavanieu
Jun 1, 2012·Drug Discovery Today. Disease Mechanisms·Courtney S SneltenJudy L Bolton
Oct 4, 2012·Toxicology·Ketan GajjarFrancis L Martin
Aug 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Idrees Ayoub ShahNazir Ahmad Dar
Jul 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Inik ChangYuichiro Tanaka
Nov 28, 2014·Frontiers in Endocrinology·Felicitas Mungenast, Theresia Thalhammer
Jul 23, 2013·International Journal of Environmental Health Research·Elvira V BräunerOle Raaschou-Nielsen
Feb 18, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krzysztof MarciniecStanisław Boryczka
Oct 8, 2016·Organic & Biomolecular Chemistry·Mohd Usman Mohd SiddiqueBhabatosh Chaudhuri
Jun 26, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alex C VeithBhagavatula Moorthy
Dec 19, 2019·Pharmacogenomics·Eric JohnsonUmang Swami
Feb 1, 2017·Journal of Biomolecular Screening·Zhiying WangMichael Zhuo Wang
Jun 10, 2017·Pharmacology Research & Perspectives·Ariane R GuthrieJessica A Martinez
Jul 1, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jiaqi WangSu Zeng
Aug 3, 2019·Journal of Experimental & Clinical Cancer Research : CR·Francesca CirilloMarcello Maggiolini
Aug 28, 2018·Bioinorganic Chemistry and Applications·Zbigniew Dutkiewicz, Renata Mikstacka
Mar 22, 2019·International Journal of Molecular Sciences·Adele ChimentoVincenzo Pezzi
Aug 6, 2019·Pharmacological Reports : PR·Oksana Maksymchuk, Vladimir Kashuba
Sep 3, 2020·Environmental Science and Pollution Research International·Muhammad Yasir Abdur RehmanJabir Hussain Syed
Jul 7, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Grażyna JanikowskaPrzemysław Jędrusik
Jan 17, 2021·Bulletin of Experimental Biology and Medicine·D S KutilinN V Porkhanova

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