CYP24A1 variant modifies the association between use of oestrogen plus progestogen therapy and colorectal cancer risk

British Journal of Cancer
Xabier Garcia-AlbenizJenny Chang-Claude

Abstract

Menopausal hormone therapy (MHT) use has been consistently associated with a decreased risk of colorectal cancer (CRC) in women. Our aim was to use a genome-wide gene-environment interaction analysis to identify genetic modifiers of CRC risk associated with use of MHT. We included 10 835 postmenopausal women (5419 cases and 5416 controls) from 10 studies. We evaluated use of any MHT, oestrogen-only (E-only) and combined oestrogen-progestogen (E+P) hormone preparations. To test for multiplicative interactions, we applied the empirical Bayes (EB) test as well as the Wald test in conventional case-control logistic regression as primary tests. The Cocktail test was used as secondary test. The EB test identified a significant interaction between rs964293 at 20q13.2/CYP24A1 and E+P (interaction OR (95% CIs)=0.61 (0.52-0.72), P=4.8 × 10(-9)). The secondary analysis also identified this interaction (Cocktail test OR=0.64 (0.52-0.78), P=1.2 × 10(-5) (alpha threshold=3.1 × 10(-4)). The ORs for association between E+P and CRC risk by rs964293 genotype were as follows: C/C, 0.96 (0.61-1.50); A/C, 0.61 (0.39-0.95) and A/A, 0.40 (0.22-0.73), respectively. Our results indicate that rs964293 modifies the association between E+P and CRC risk. T...Continue Reading

Associated Clinical Trials

Dec 31, 2014·Cornelia Ulrich

References

Nov 1, 1985·American Journal of Epidemiology·P BruzziC Schairer
Apr 5, 1995·Journal of the National Cancer Institute·E E CalleC W Heath
Sep 13, 1996·Science·N Risch, K Merikangas
Dec 16, 1998·Annals of Internal Medicine·F GrodsteinM J Stampfer
May 21, 1999·The American Journal of Medicine·F GrodsteinM J Stampfer
Jul 27, 2001·Biochemical and Biophysical Research Communications·P BareisM Peterlik
Jun 1, 1955·Annals of Human Genetics·B WOOLF
Mar 5, 2004·The New England Journal of Medicine·Rowan T ChlebowskiUNKNOWN Women's Health Initiative Investigators
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Garnet L AndersonUNKNOWN Women's Health Initiative Steering Committee
May 3, 2005·Nature Reviews. Cancer·Graham A Colditz, Susan E Hankinson
Oct 29, 2005·Nature·UNKNOWN International HapMap Consortium
Jun 8, 2007·Nature·UNKNOWN Wellcome Trust Case Control Consortium
Jun 19, 2007·Nature Genetics·Jonathan MarchiniPeter Donnelly
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Sep 19, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Damien Matusiak, Richard V Benya
Nov 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Polly A NewcombUNKNOWN Colon Cancer Family Registry
Dec 20, 2007·International Journal of Cancer. Journal International Du Cancer·Eric L DingEdward L Giovannucci
Jan 18, 2008·Genetic Epidemiology·Clive J HoggartDavid J Balding
Feb 27, 2008·Genetic Epidemiology·Frank Dudbridge, Arief Gusnanto
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jill R JohnsonAndrew Flood
Aug 26, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gad RennertStephen B Gruber
Aug 27, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Linda M DongUlrike Peters
Nov 26, 2009·Biometrics·Bhramar MukherjeeNilanjan Chatterjee
Feb 4, 2010·Cancer Research·Martha L SlatteryUlrike Peters
Apr 28, 2010·Gastroenterology·Andrew T Chan, Edward L Giovannucci
Oct 26, 2010·Lancet·Robert Benamouzig, Bernard Uzzan
Nov 9, 2010·Genetic Epidemiology·Yun LiGonçalo R Abecasis
Mar 2, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jane C FigueiredoGraham Casey
Mar 3, 2011·International Journal of Cancer. Journal International Du Cancer·Kueiyu Joshua LinEdward L Giovannucci
Apr 12, 2011·Cancer Causes & Control : CCC·Martha L SlatteryRoger K Wolff
Jun 2, 2011·BMC Medical Genetics·Jennifer H LinShumin M Zhang
Jun 15, 2011·International Journal of Cancer. Journal International Du Cancer·Jane GreenValerie Beral
Jul 16, 2011·Human Genetics·Ulrike PetersGraham Casey
Jul 20, 2011·Genetic Epidemiology·Shuo JiaoUlrike Peters
Jun 21, 2012·Genetic Epidemiology·Li HsuCharles Kooperberg
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S SimonRoss L Prentice
Dec 26, 2012·Gastroenterology·Ulrike PetersUNKNOWN Colon Cancer Family Registry and the Genetics and Epidemiology of Colorectal Cancer Consortium

❮ Previous
Next ❯

Citations

Mar 23, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Timur Mitin
Mar 1, 2018·International Journal of Epidemiology·Mark A JenkinsUNKNOWN Colon Cancer Family Registry Cohort Investigators
Dec 12, 2018·International Journal of Cancer. Journal International Du Cancer·Tian YangEvropi Theodoratou
Apr 24, 2020·Journal of the National Cancer Institute·Peter T CampbellUlrike Peters
Jun 19, 2018·Journal of the National Cancer Institute·Marjorie L McCulloughStephanie A Smith-Warner
Feb 20, 2018·Gastroenterology·Jihyoun JeonUNKNOWN Colorectal Transdisciplinary Study and Genetics and Epidemiology of Colorectal Cancer Consortium
Jul 31, 2020·Anti-cancer Agents in Medicinal Chemistry·Afsane Bahrami, Amirhossein Sahebkar

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw
genotyping

Software Mentioned

GTEx
IMPUTE
EIGENSTRAT
MACH
BEAGLE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.