CYP27B1 as an instrument gene to investigate the causal relationship between vitamin D deficiency and obesity: a family-based study.

European Journal of Clinical Nutrition
Songcheng YuXing Li

Abstract

Vitamin D deficiency was associated with obesity. However, the causal relationship remains controversial. We hypothesized that there would be family-based associations in both vitamin D deficient families and obese families for the SNPs associated with vitamin D deficiency, if vitamin D deficiency was a causal factor of obesity. We aimed to investigate the family-based association of SNPs in CYP27B1 with both vitamin D deficiency and obesity. Four hundred and nineteen pedigrees containing 1505 rural individuals aged from 18 to 79 years in Henan Province of China were included in this study. Family-based associations of rs10877012 and rs4646536 in CYP27B1 with vitamin D deficiency and obesity were investigated. Serum 25(OH)D3 concentration <20 μg/L was defined as vitamin D deficiency. BMI ≥ 28 kg/m2 was applied for obesity definition. Taqman assays were applied for SNP genotyping. Family-based associations were investigated with FBAT software. It was shown that vitamin D deficiency was a risk factor of obesity (adjusted OR: 1.332, 95% CI: 1.042-1.703, P = 0.022). Furthermore, there were family-based associations for allele T of rs10877012 and allele T of rs4646536 in both vitamin D deficient families and obese families (P < 0.05...Continue Reading

References

Sep 1, 2000·The American Journal of Clinical Nutrition·J WortsmanM F Holick
Aug 12, 2008·The American Journal of Clinical Nutrition·Sarah-Michelle OrtonGeorge C Ebers
Jul 11, 2014·Frontiers in Physiology·Shivaprakash J MuttKarl-Heinz Herzig

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

FABT
Haploview
SPSS
FBAT

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